Department of Chemical & Biological Engineering, Princeton University, Princeton, NJ 08544, United States.
Curr Opin Biotechnol. 2013 Oct;24(5):954-61. doi: 10.1016/j.copbio.2013.04.006. Epub 2013 May 4.
Morphogenesis, the creation of tissue and organ architecture, is a series of complex and dynamic processes driven by genetic programs, microenvironmental cues, and intercellular interactions. Elucidating the physical mechanisms that generate tissue form is key to understanding development, disease, and the strategies needed for regenerative therapies. Advancements in imaging technologies, genetic recombination techniques, laser ablation, and microfabricated tissue models have enabled quantitative descriptions of the cellular motions and tissue deformations and stresses with unprecedented temporal and spatial resolution. Using these data synergistically with increasingly more sophisticated physical, mathematical, and computational models will unveil the physical mechanisms that drive morphogenesis.
形态发生是组织和器官结构的形成过程，是一系列由遗传程序、微环境线索和细胞间相互作用驱动的复杂和动态过程。阐明产生组织形态的物理机制是理解发育、疾病以及再生治疗所需策略的关键。成像技术、基因重组技术、激光烧蚀和微制造组织模型的进步使人们能够以前所未有的时空分辨率定量描述细胞运动和组织变形以及应力。通过将这些数据与越来越复杂的物理、数学和计算模型协同使用，将揭示驱动形态发生的物理机制。
