Xie T X
Hebei Medical College, Shijiazhuang.
Zhonghua Zhong Liu Za Zhi. 1990 Jan;12(1):21-3.
Aspergillus versicolor was isolated from the gastric juice of patients with chronic stomach diseases in high-risk area of gastric cancer. Mice fed with aspergillus-inoculated corn flour developed adenocarcinoma of the lung in 15 of 35 mice (42.9%) and atypical hyperplasia of the glandular stomach in 13 of 35 mice (37.4%). Sterigmatocystin was identified by HPLC and fluorescence spectrophotometry in the extract of aspergillus-inoculated corn flour. The results suggest that the mycotoxin sterigmatocystin is a potential carcinogen in human.
从胃癌高发地区慢性胃病患者的胃液中分离出杂色曲霉。用接种了曲霉的玉米粉喂养的小鼠，35只中有15只（42.9%）发生了肺癌腺癌，35只中有13只（37.4%）发生了腺胃非典型增生。通过高效液相色谱法和荧光分光光度法在接种曲霉的玉米粉提取物中鉴定出了柄曲霉素。结果表明，霉菌毒素柄曲霉素是一种潜在的人类致癌物。
