Laboratory of Veterinary Infectious Disease, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034-8628, Japan.
Antiviral Res. 2013 Aug;99(2):100-7. doi: 10.1016/j.antiviral.2013.04.016. Epub 2013 May 3.
Feline infectious peritonitis (FIP) is a feline coronavirus-induced fatal disease in domestic and wild cats. Several studies have investigated potential treatments for FIP. However, there have been no reports on agents that have exhibited a therapeutic effect. Recently, chloroquine has been reported to antiviral effect. We investigated whether chloroquine can be used to treat FIP in vitro and in vivo. It was demonstrated that chloroquine has inhibitory effect against the replication of FIPV and anti-inflammatory effect in vitro. In vivo study using cats with experimentally induced FIP, the clinical score of chloroquine-treatment groups were better than in chloroquine-untreated group. However, alanine aminotransferase levels increased in the chloroquine-treated groups. It will be necessary to further investigate the possibility of FIP treatment with a combination of chloroquine and other agents.
猫传染性腹膜炎（FIP）是一种由猫冠状病毒引起的致命疾病，在国内外的猫中均有发生。已有多项研究探索了 FIP 的潜在治疗方法，但尚未有报道称有哪种药物具有治疗效果。最近有报道称氯喹具有抗病毒作用。我们研究了氯喹是否可以在体外和体内用于治疗 FIP。结果表明，氯喹在体外具有抑制 FIPV 复制和抗炎作用。在使用实验性诱导 FIP 的猫进行的体内研究中，氯喹治疗组的临床评分优于未用氯喹治疗组。然而，氯喹治疗组的丙氨酸氨基转移酶水平升高。需要进一步研究氯喹与其他药物联合治疗 FIP 的可能性。
