生物测定法测定伏立康唑血清浓度，为临床实验室治疗药物监测提供了一种有效的方法。
Determination of voriconazole serum concentration by bioassay, a valid method for therapeutic drug monitoring for clinical laboratories.
机构信息
Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
出版信息
Antimicrob Agents Chemother. 2013 Jul;57(7):3437-40. doi: 10.1128/AAC.00323-13. Epub 2013 May 6.
Abstract
We describe here a simple, fast, and reliable bioassay method for therapeutic drug monitoring of voriconazole. Fifty-eight clinical and external quality control samples were evaluated with this microbiological assay, and results were compared with those obtained with a previously validated chromatographic method. A good correlation between both assays was observed. This particular microbiological method was demonstrated to be simple and offers enough precision and accuracy to perform voriconazole therapeutic drug monitoring in laboratories without specialized equipment.
摘要
我们在这里描述了一种简单、快速和可靠的伏立康唑治疗药物监测的生物测定方法。使用这种微生物测定法评估了 58 个临床和外部质量控制样本，结果与先前验证的色谱方法获得的结果进行了比较。两种测定方法之间存在良好的相关性。该特定的微生物方法被证明是简单的，并提供了足够的精密度和准确性，可在没有专用设备的实验室中进行伏立康唑治疗药物监测。
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1
Development and validation of a fast HPLC/photodiode array detection method for the measurement of voriconazole in human serum samples. A reference laboratory experience.
Enferm Infecc Microbiol Clin. 2013 Jan;31(1):23-8. doi: 10.1016/j.eimc.2012.03.003. Epub 2012 Jul 8.
2
The effect of therapeutic drug monitoring on safety and efficacy of voriconazole in invasive fungal infections: a randomized controlled trial.
Clin Infect Dis. 2012 Oct;55(8):1080-7. doi: 10.1093/cid/cis599. Epub 2012 Jul 3.
3
Challenging recommended oral and intravenous voriconazole doses for improved efficacy and safety: population pharmacokinetics-based analysis of adult patients with invasive fungal infections.
Clin Infect Dis. 2012 Aug;55(3):381-90. doi: 10.1093/cid/cis437. Epub 2012 May 18.
4
HPLC/UV or bioassay: two valid methods for posaconazole quantification in human serum samples.
Clin Microbiol Infect. 2012 Dec;18(12):1229-35. doi: 10.1111/j.1469-0691.2011.03732.x. Epub 2011 Dec 22.
5
Comparison and evaluation of a novel bioassay and high-performance liquid chromatography for the clinical measurement of serum voriconazole concentrations.
Mycoses. 2011 Sep;54(5):e421-8. doi: 10.1111/j.1439-0507.2010.01938.x. Epub 2010 Jul 28.
6
Simultaneous determination of five systemic azoles in plasma by high-performance liquid chromatography with ultraviolet detection.
J Pharm Biomed Anal. 2009 Dec 5;50(5):932-8. doi: 10.1016/j.jpba.2009.06.030. Epub 2009 Jun 24.
7
Simultaneous determination of voriconazole and posaconazole concentrations in human plasma by high-performance liquid chromatography.
Antimicrob Agents Chemother. 2009 Jul;53(7):3140-2. doi: 10.1128/AAC.00213-09. Epub 2009 Apr 20.
8
Serial plasma voriconazole concentrations after allogeneic hematopoietic stem cell transplantation.
Antimicrob Agents Chemother. 2009 May;53(5):1793-6. doi: 10.1128/AAC.01316-08. Epub 2009 Feb 17.
9
Antifungal therapeutic drug monitoring: established and emerging indications.
Antimicrob Agents Chemother. 2009 Jan;53(1):24-34. doi: 10.1128/AAC.00705-08. Epub 2008 Oct 27.
10
Therapeutic drug monitoring of voriconazole.
Ther Drug Monit. 2008 Aug;30(4):403-11. doi: 10.1097/FTD.0b013e31817b1a95.
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