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基质辅助激光解吸电离飞行时间质谱技术在伏立康唑治疗药物监测中的新应用。

A New Application of MALDI Biotyper for a Potential Use in Therapeutic Drug Monitoring of Voriconazole.

机构信息

Clinical Microbiology and Parasitology Department, Hospital Universitario La Paz, IdiPaz, Madrid, Spain.

出版信息

Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0245820. doi: 10.1128/AAC.02458-20.

DOI:10.1128/AAC.02458-20
PMID:33972255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8284431/
Abstract

We present a proof-of-concept study on the use of MALDI Biotyper to detect and monitor the levels of voriconazole in human serum. A simple extraction-concentration method and a MALDI Biotyper protocol were developed, and a parent ion of voriconazole (1 H) could be detected and quantified with good reproducibility. Our results point to a new application of MALDI Biotyper for therapeutic drug monitoring.

摘要

我们提出了一项使用 MALDI Biotyper 检测和监测人血清中伏立康唑水平的概念验证研究。开发了一种简单的提取-浓缩方法和 MALDI Biotyper 方案，可以检测和定量伏立康唑的母离子（1 H），具有良好的重现性。我们的结果表明 MALDI Biotyper 可用于治疗药物监测的新应用。

相似文献

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2
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本文引用的文献

1
Application of the MALDI Biotyper to clinical microbiology: progress and potential.基质辅助激光解吸电离飞行时间质谱技术在临床微生物学中的应用：进展与潜力。
Expert Rev Proteomics. 2018 Mar;15(3):193-202. doi: 10.1080/14789450.2018.1438193. Epub 2018 Feb 13.
2
Therapeutic drug monitoring for invasive mould infections and disease: pharmacokinetic and pharmacodynamic considerations.侵袭性霉菌感染与疾病的治疗药物监测：药代动力学与药效学考量
J Antimicrob Chemother. 2017 Mar 1;72(suppl_1):i12-i18. doi: 10.1093/jac/dkx029.
3
Plasma Voriconazole Estimation by HPLC.采用高效液相色谱法测定血浆伏立康唑浓度
Indian J Clin Biochem. 2016 Apr;31(2):209-14. doi: 10.1007/s12291-015-0507-z. Epub 2015 May 1.
4
[Clinical indications for therapeutic drug monitoring of antifungal agents. In the way for optimizing the treatment of fungal infection].[抗真菌药物治疗药物监测的临床指征。迈向优化真菌感染治疗之路]
Rev Esp Quimioter. 2014 Mar;27(1):1-16.
5
Determination of voriconazole serum concentration by bioassay, a valid method for therapeutic drug monitoring for clinical laboratories.生物测定法测定伏立康唑血清浓度，为临床实验室治疗药物监测提供了一种有效的方法。
Antimicrob Agents Chemother. 2013 Jul;57(7):3437-40. doi: 10.1128/AAC.00323-13. Epub 2013 May 6.
6
Development and validation of a fast HPLC/photodiode array detection method for the measurement of voriconazole in human serum samples. A reference laboratory experience.开发并验证了一种快速高效液相色谱/光电二极管阵列检测法，用于测量人血清样品中的伏立康唑。参考实验室经验。
Enferm Infecc Microbiol Clin. 2013 Jan;31(1):23-8. doi: 10.1016/j.eimc.2012.03.003. Epub 2012 Jul 8.