SatR 是氟喹诺酮外排泵 SatAB 的抑制剂。
SatR is a repressor of fluoroquinolone efflux pump SatAB.
机构信息
Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain.
出版信息
Antimicrob Agents Chemother. 2013 Jul;57(7):3430-3. doi: 10.1128/AAC.00515-13. Epub 2013 May 6.
Abstract
Streptococcus suis is an emerging zoonotic agent responsible for high-mortality outbreaks among the human population in China. In this species, the ABC transporter SatAB mediates fluoroquinolone resistance when overexpressed. Here, we describe and characterize satR, an open reading frame (ORF) encoding a MarR superfamily regulator that acts as a repressor of satAB. satR is cotranscribed with satAB, and its interruption entails the overexpression of the pump, leading to a clinically relevant increase in resistance to fluoroquinolones.
摘要
猪链球菌是一种新兴的人畜共患病原体，在中国，它可导致人类高发死亡率的疫情爆发。在该物种中，ABC 转运蛋白 SatAB 过表达时介导氟喹诺酮类药物耐药。在此，我们描述并鉴定了 satR，这是一个编码 MarR 超级家族调控因子的开放阅读框（ORF），其作为 satAB 的阻遏物发挥作用。satR 与 satAB 共转录，其阻断会导致泵的过表达，从而导致对氟喹诺酮类药物的临床相关耐药性增加。
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