Department of Obstetrics and Gynecology, UNC School of Medicine, Chapel Hill, NC 27599, USA.
BJOG. 2013 Aug;120(9):1116-22. doi: 10.1111/1471-0528.12255. Epub 2013 May 8.
To assess the relationship between unintended pregnancy and postpartum depression.
Secondary analysis of data from a prospective pregnancy cohort.
The study was performed at the University of North Carolina prenatal care clinics.
POPULATION/SAMPLE: Pregnant women enrolled for prenatal care at the University of North Carolina Hospital Center.
Participants were questioned about pregnancy intention at 15-19 weeks of gestation, and classified as having an intended, mistimed or unwanted pregnancy. They were evaluated for postpartum depression at 3 and 12 months postpartum. Log binomial regression was used to assess the relationship between unintended pregnancy and depression, controlling for confounding by demographic factors and reproductive history.
Depression at 3 and 12 months postpartum, defined as Edinburgh Postpartum Depression Scale score >13.
Data were analysed for 688 women at 3 months and 550 women at 12 months. Depression was more likely in women with unintended pregnancies at both 3 months (risk ratio [RR] 2.1, 95% confidence interval [95% CI] 1.2-3.6) and 12 months (RR 3.6, 95% CI 1.8-7.1). Using multivariable analysis adjusting for confounding by age, poverty and education level, women with unintended pregnancies were twice as likely to have postpartum depression at 12 months (RR 2.0, 95% CI 0.96-4.0).
While many elements may contribute to postpartum depression, unintended pregnancy could also be a contributing factor. Women with unintended pregnancy may have an increased risk of depression up to 1 year postpartum.
评估意外怀孕与产后抑郁的关系。
对前瞻性妊娠队列数据的二次分析。
北卡罗来纳大学产前保健诊所。
人群/样本:在北卡罗来纳大学医院中心接受产前保健的孕妇。
在妊娠 15-19 周时,对参与者进行妊娠意图询问,并分为计划内妊娠、时机不当妊娠和非意愿妊娠。在产后 3 个月和 12 个月时评估产后抑郁。采用对数二项式回归评估意外妊娠与抑郁之间的关系,同时控制人口统计学因素和生殖史混杂因素。
产后 3 个月和 12 个月的抑郁,定义为爱丁堡产后抑郁量表评分>13。
在产后 3 个月时对 688 名妇女和产后 12 个月时对 550 名妇女进行了数据分析。在产后 3 个月(风险比 [RR] 2.1,95%置信区间 [95%CI] 1.2-3.6)和产后 12 个月(RR 3.6,95%CI 1.8-7.1)时,意外妊娠的女性更有可能出现抑郁。使用多变量分析调整年龄、贫困和教育水平混杂因素后,意外妊娠的女性在产后 12 个月时更有可能出现产后抑郁(RR 2.0,95%CI 0.96-4.0)。
尽管许多因素可能导致产后抑郁,但意外怀孕也可能是一个促成因素。意外妊娠的女性在产后 1 年内患抑郁症的风险可能会增加。