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妊娠意向与产后抑郁:一项前瞻性队列的次级数据分析。

Pregnancy intention and postpartum depression: secondary data analysis from a prospective cohort.

机构信息

Department of Obstetrics and Gynecology, UNC School of Medicine, Chapel Hill, NC 27599, USA.

出版信息

BJOG. 2013 Aug;120(9):1116-22. doi: 10.1111/1471-0528.12255. Epub 2013 May 8.

DOI:10.1111/1471-0528.12255
PMID:23651010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3708972/
Abstract

OBJECTIVE

To assess the relationship between unintended pregnancy and postpartum depression.

DESIGN

Secondary analysis of data from a prospective pregnancy cohort.

SETTING

The study was performed at the University of North Carolina prenatal care clinics.

POPULATION/SAMPLE: Pregnant women enrolled for prenatal care at the University of North Carolina Hospital Center.

METHODS

Participants were questioned about pregnancy intention at 15-19 weeks of gestation, and classified as having an intended, mistimed or unwanted pregnancy. They were evaluated for postpartum depression at 3 and 12 months postpartum. Log binomial regression was used to assess the relationship between unintended pregnancy and depression, controlling for confounding by demographic factors and reproductive history.

MAIN OUTCOME MEASURES

Depression at 3 and 12 months postpartum, defined as Edinburgh Postpartum Depression Scale score >13.

RESULTS

Data were analysed for 688 women at 3 months and 550 women at 12 months. Depression was more likely in women with unintended pregnancies at both 3 months (risk ratio [RR] 2.1, 95% confidence interval [95% CI] 1.2-3.6) and 12 months (RR 3.6, 95% CI 1.8-7.1). Using multivariable analysis adjusting for confounding by age, poverty and education level, women with unintended pregnancies were twice as likely to have postpartum depression at 12 months (RR 2.0, 95% CI 0.96-4.0).

CONCLUSION

While many elements may contribute to postpartum depression, unintended pregnancy could also be a contributing factor. Women with unintended pregnancy may have an increased risk of depression up to 1 year postpartum.

摘要

目的

评估意外怀孕与产后抑郁的关系。

设计

对前瞻性妊娠队列数据的二次分析。

地点

北卡罗来纳大学产前保健诊所。

人群/样本:在北卡罗来纳大学医院中心接受产前保健的孕妇。

方法

在妊娠 15-19 周时,对参与者进行妊娠意图询问,并分为计划内妊娠、时机不当妊娠和非意愿妊娠。在产后 3 个月和 12 个月时评估产后抑郁。采用对数二项式回归评估意外妊娠与抑郁之间的关系,同时控制人口统计学因素和生殖史混杂因素。

主要观察指标

产后 3 个月和 12 个月的抑郁,定义为爱丁堡产后抑郁量表评分>13。

结果

在产后 3 个月时对 688 名妇女和产后 12 个月时对 550 名妇女进行了数据分析。在产后 3 个月(风险比 [RR] 2.1,95%置信区间 [95%CI] 1.2-3.6)和产后 12 个月(RR 3.6,95%CI 1.8-7.1)时,意外妊娠的女性更有可能出现抑郁。使用多变量分析调整年龄、贫困和教育水平混杂因素后,意外妊娠的女性在产后 12 个月时更有可能出现产后抑郁(RR 2.0,95%CI 0.96-4.0)。

结论

尽管许多因素可能导致产后抑郁,但意外怀孕也可能是一个促成因素。意外妊娠的女性在产后 1 年内患抑郁症的风险可能会增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bced/3708972/90a20decaf79/nihms457562f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bced/3708972/d3033188aae8/nihms457562f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bced/3708972/90a20decaf79/nihms457562f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bced/3708972/d3033188aae8/nihms457562f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bced/3708972/90a20decaf79/nihms457562f2.jpg

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