Department of Dermatology, National Skin Centre, Singapore.
Photodermatol Photoimmunol Photomed. 2013 Jun;29(3):116-20. doi: 10.1111/phpp.12034.
Photopatch testing is important for diagnosing photoallergic contact dermatitis. We aimed to evaluate the use of photopatch test at the National Skin Centre, Singapore.
All patients who had photopatch tests done between 2007 and 2011 at the National Skin Centre were included.
Twenty-two patients were included. The mean age was 40.2. Female : male ratio was 3.4. The ethnic groups were Chinese (68%), Malay (4%), Indian (14%) and others (14%). Ten out of 22 patients (45.5%) had a positive photopatch test. There were 20 positive photopatch test reactions found in these 10 patients, and all 20 positive reactions were of current relevance. The frequencies of the positive photopatch test reactions were 2-hydroxy-4-methoxybenzophenone (oxybenzone) (n = 6), 2-hydroxymethoxymethylbenzophenone (mexenone) (n = 3), 2-ethylhexyl-4-dimethylaminobenzoate (n = 1), ketoprofen gel (n = 1) and the patient's own product (n = 9).
Our study suggests that sunscreen is the most common photoallergen to date as opposed to musk ambrette, which was the most common photoallergen in our earlier study in 1991-1993. This finding is similar to the recent European Multicentre Photopatch Test Study.
光变应原检测对诊断光接触性皮炎具有重要意义。本研究旨在评估新加坡国家皮肤中心光变应原检测的应用情况。
所有于 2007 年至 2011 年在国家皮肤中心行光变应原检测的患者均被纳入本研究。
共纳入 22 例患者。患者平均年龄为 40.2 岁。女性与男性比例为 3.4:1。种族分布为华人（68%）、马来人（4%）、印度人（14%）和其他人种（14%）。22 例患者中有 10 例（45.5%）光变应原检测阳性。10 例患者中有 20 个阳性光变应原检测反应，且均与当前相关。20 个阳性光变应原检测反应中，2-羟基-4-甲氧基二苯甲酮（氧苯酮）（n=6）、2-羟基-4-甲氧基二苯甲酮（羟苯甲酮）（n=3）、2-乙基己基-4-二甲氨基苯甲酸酯（n=1）、酮洛芬凝胶（n=1）和患者自身产品（n=9）的阳性率较高。
与我们 1991-1993 年的早期研究中最常见的光变应原麝香紫葵不同，我们的研究表明，防晒霜是迄今为止最常见的光变应原。这一发现与最近的欧洲多中心光变应原斑贴试验研究结果相似。
