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白细胞介素-22 结合蛋白 (IL-22BP) 由常规树突状细胞的亚群组成性表达，并被维甲酸强烈诱导。

Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid.

机构信息

1] INSERM Center of Research in Transplantation and Immunology, UMR1064, Nantes, France [2] CHU Nantes, Institut de Transplantation Urologie Néphrologie (ITUN), Nantes, France [3] CHU Nantes, Laboratoire d'immunologie, Nantes, France [4] Faculté de Médecine, Université de Nantes, Nantes, France.

1] INSERM Center of Research in Transplantation and Immunology, UMR1064, Nantes, France [2] CHU Nantes, Institut de Transplantation Urologie Néphrologie (ITUN), Nantes, France.

出版信息

Mucosal Immunol. 2014 Jan;7(1):101-13. doi: 10.1038/mi.2013.28. Epub 2013 May 8.

DOI:10.1038/mi.2013.28
PMID:23653115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4291114/
Abstract

Interleukin-22 (IL-22) is mainly produced at barrier surfaces by T cells and innate lymphoid cells and is crucial to maintain epithelial integrity. However, dysregulated IL-22 action leads to deleterious inflammation and is involved in diseases such as psoriasis, intestinal inflammation, and cancer. IL-22 binding protein (IL-22BP) is a soluble inhibitory IL-22 receptor and may represent a crucial regulator of IL-22. We show both in rats and mice that, in the steady state, the main source of IL-22BP is constituted by a subset of conventional dendritic cells (DCs) in lymphoid and non-lymphoid tissues. In mouse intestine, IL-22BP was specifically expressed in lamina propria CD103(+)CD11b(+) DC. In humans, IL-22BP was expressed in immature monocyte-derived DC and strongly induced by retinoic acid but dramatically reduced upon maturation. Our data suggest that a subset of immature DCs may actively participate in the regulation of IL-22 activity in the gut by producing high levels of IL-22BP.

摘要

白细胞介素-22 (IL-22) 主要由 T 细胞和固有淋巴细胞在屏障表面产生，对维持上皮细胞完整性至关重要。然而，IL-22 作用失调会导致有害炎症，并与银屑病、肠道炎症和癌症等疾病有关。白细胞介素-22 结合蛋白 (IL-22BP) 是一种可溶性抑制性白细胞介素-22 受体，可能是白细胞介素-22 的重要调节剂。我们在大鼠和小鼠中均表明，在稳态下，IL-22BP 的主要来源由淋巴组织和非淋巴组织中常规树突状细胞 (DC) 的一个亚群构成。在小鼠肠道中，IL-22BP 特异性表达于固有层 CD103(+)CD11b(+) DC。在人类中，IL-22BP 在未成熟单核细胞衍生的 DC 中表达，并被维甲酸强烈诱导，但在成熟时显著降低。我们的数据表明，一组未成熟的 DC 可能通过产生高水平的 IL-22BP 而积极参与肠道中 IL-22 活性的调节。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d4/4291114/401414e7df5e/nihms-498121-f0009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d4/4291114/401414e7df5e/nihms-498121-f0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d4/4291114/c22b74afe9ca/nihms-498121-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d4/4291114/fce1992806f3/nihms-498121-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d4/4291114/96e555d2dbd5/nihms-498121-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d4/4291114/8788e1b99252/nihms-498121-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d4/4291114/42915e9238c3/nihms-498121-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d4/4291114/a8ab859afff0/nihms-498121-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d4/4291114/fe652bae2fd5/nihms-498121-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d4/4291114/8d42fd4641fd/nihms-498121-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d4/4291114/401414e7df5e/nihms-498121-f0009.jpg

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