丹麦中老年双胞胎人群中金黄色葡萄球菌鼻腔定植的危险因素。
Risk factors for Staphylococcus aureus nasal colonization in Danish middle-aged and elderly twins.
机构信息
Microbiology Research and Infection Control, Statens Serum Institut, Copenhagen, Denmark,
出版信息
Eur J Clin Microbiol Infect Dis. 2013 Oct;32(10):1321-6. doi: 10.1007/s10096-013-1882-0. Epub 2013 May 9.
Abstract
Staphylococcus aureus is a human commensal bacterium found in the nasal cavity and other body sites. Identifying risk factors for S. aureus nasal carriage is of interest, as nasal carriage is a risk factor for subsequent invasive infection. We recently investigated the influence of host genetics on S. aureus carriage in Danish middle-aged and elderly twins, which indicated no significant heritability that could account for the observed S. aureus carriage. In the present study, we performed a questionnaire-based study of S. aureus colonization on the same cohort of 2,196 Danish middle-aged and elderly twins to identify specific risk factors for S. aureus nasal colonization, including analyzing the paired twins (n = 478) that were discordant for S. aureus colonization. We found associations between risk factors and S. aureus nasal colonization among middle-aged and elderly twins, including age, male gender, psoriasis, and atopic diseases. Also, present living on a farm is clearly associated with S. aureus colonization, while smoking had a borderline statistically significant protective effect.
摘要
金黄色葡萄球菌是一种存在于鼻腔和其他身体部位的人体共生细菌。确定金黄色葡萄球菌鼻腔携带的危险因素很有意义，因为鼻腔携带是随后发生侵袭性感染的危险因素。我们最近研究了宿主遗传学对丹麦中年和老年双胞胎金黄色葡萄球菌携带的影响，结果表明没有明显的遗传性可以解释观察到的金黄色葡萄球菌携带。在本研究中，我们对同一队列的 2196 名丹麦中年和老年双胞胎进行了一项基于问卷调查的金黄色葡萄球菌定植研究，以确定金黄色葡萄球菌鼻腔定植的特定危险因素，包括分析对金黄色葡萄球菌定植不一致的双胞胎（n=478）。我们发现中年和老年双胞胎中，危险因素与金黄色葡萄球菌鼻腔定植之间存在关联，包括年龄、男性、银屑病和特应性疾病。此外，目前居住在农场与金黄色葡萄球菌定植明显相关，而吸烟具有统计学意义上的保护作用。
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