Department of Cardiothoracic Surgery, The Mount Sinai Medical Center, New York, NY, USA.
Eur J Cardiothorac Surg. 2014 Jan;45(1):132-7; discussion 137-8. doi: 10.1093/ejcts/ezt234. Epub 2013 May 8.
We set out to determine if intraoperative pre-bypass transoesophageal echocardiography could assist in predicting which patients are at greatest risk for systolic anterior motion (SAM) after mitral valve repair (MVR).
Three hundred and seventy-five consecutive patients who underwent reconstructive MVR surgery for degenerative disease were included. Data were collected using intraoperative echocardiographic images taken prior to the initiation of cardiopulmonary bypass. Based on the physiology of SAM, we postulated that 11 parameters could be potential risk factors for SAM: left ventricular ejection fraction (LVEF), left ventricular end-systolic dimension, left ventricular end-diastolic dimension (LVEDD), basal septal diameter (basal-interventricular septal diameter in diastole (IVDd)), mid-ventricular septal diameter (mid-IVDd), coaptation-septal distance (c-sept), anterior leaflet height, posterior leaflet height, aorto-mitral angle, mitral annular diameter and left atrial diameter. These parameters were measured and recorded by a blinded single operator. Independent predictors of SAM were identified using multiple logistic regression analysis.
Of the 375 patients, 345 (92%) did not develop SAM (No-SAM group), while 30 (8%) developed intraoperative or postoperative SAM (SAM group). The mean age was 56.8 ± 12.8 and 56.7 ± 13.8 in the No-SAM and SAM groups, respectively. The incidence of fibroelastic deficiency, forme fruste and Barlow's disease was similar in both groups. All patients received a complete annuloplasty ring as part of the repair. There was no statistical difference in the mean ring size used in each group. EF was similar in the No-SAM (56.2% ± 8.1) and SAM (57.0% ± 9.2) P = 0.63) groups. Independent predictors of developing SAM after valve repair were: EDD <45 mm [odds ratio (OR) 3.90; P = 0.028], aorto-mitral angle <120° (OR 2.74; P = 0.041), coaptation-septum distance <25 mm (OR 5.09; P = 0.003), posterior leaflet height >15 mm (OR 3.80; P = 0.012) and basal septal diameter ≥ 15 mm (OR 3.63; P = 0.039).
The risk for SAM can be predicted using intraoperative transoesophageal echocardiography. The combination of a smaller left ventricle, tall posterior leaflet, narrow aorto-mitral angle and enlarged basal septum significantly increases the risk for SAM. Knowing these parameters prior to valve repair can assist the surgeon in adjusting their repair technique to minimize the risk.
我们旨在确定术中体外循环前经食管超声心动图是否有助于预测哪些患者在二尖瓣修复(MVR)后发生收缩期前向运动(SAM)的风险最大。
纳入 375 例连续行退行性病变二尖瓣修复术的患者。使用体外循环前获取的术中超声心动图图像收集数据。基于 SAM 的生理学,我们假设 11 个参数可能是 SAM 的潜在危险因素:左心室射血分数(LVEF)、左心室收缩末期内径、左心室舒张末期内径(LVEDD)、基底室间隔直径(舒张期的基底部-室间隔直径(IVDd))、中室间隔直径(中-IVDd)、瓣叶对合-室间隔距离(c-sept)、前瓣叶高度、后瓣叶高度、主动脉瓣-二尖瓣角度、二尖瓣环直径和左心房直径。这些参数由一位经验丰富的操作人员进行测量和记录。使用多元逻辑回归分析确定 SAM 的独立预测因子。
在 375 例患者中,345 例(92%)未发生 SAM(无 SAM 组),30 例(8%)发生术中或术后 SAM(SAM 组)。无 SAM 组和 SAM 组的平均年龄分别为 56.8 ± 12.8 和 56.7 ± 13.8。两组的纤维弹性缺失、形式不成熟和巴氏病的发生率相似。所有患者均接受了完整的瓣环成形术作为修复的一部分。两组使用的平均环大小无统计学差异。无 SAM 组(56.2%±8.1)和 SAM 组(57.0%±9.2)的 EF 相似,P=0.63)。瓣膜修复后发生 SAM 的独立预测因子为:EDD<45mm[比值比(OR)3.90;P=0.028]、主动脉瓣-二尖瓣角度<120°(OR 2.74;P=0.041)、瓣叶对合-室间隔距离<25mm(OR 5.09;P=0.003)、后瓣叶高度>15mm(OR 3.80;P=0.012)和基底室间隔直径≥15mm(OR 3.63;P=0.039)。
SAM 的风险可以通过术中经食管超声心动图来预测。较小的左心室、高后瓣叶、狭窄的主动脉瓣-二尖瓣角度和扩大的基底室间隔的组合显著增加了 SAM 的风险。在瓣膜修复前了解这些参数可以帮助外科医生调整修复技术,以最大限度地降低风险。