Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul, 136-705, Korea.
Mol Biol Rep. 2013 Aug;40(8):5191-203. doi: 10.1007/s11033-013-2621-4. Epub 2013 May 9.
The aim of this study was to determine whether tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) promoter polymorphisms confer susceptibility to periodontitis in ethnically different populations. A literature search was performed using PubMed and Embase and a meta-analysis of the identified studies was conducted to explore the associations between TNF-α -308 A/G, -238 A/G, IL-6 promoter -174 G/C and -572 G/C polymorphisms and periodontitis. Seventeen comparison studies for the TNF-α -308 A/G polymorphism and three studies for the TNF-α -238 A/G polymorphism were included in the meta-analysis. And 16 separate studies for the IL-6 -174 G/C polymorphism and 10 studies for the IL-6 -572 G/C polymorphism were considered in our meta-analysis. Analysis after stratification by ethnicity indicated that the TNF-α -308 A allele was associated with periodontitis in Brazilian, Asian, and Turkish populations (OR=0.637, 95% CI=0.447-0.907, p=0.013; OR=0.403, 95% CI=0.204-0.707, p=0.009; OR=1.818, 95; % CI=1.036-3.189, p=0.037). The meta-analysis showed no association between the TNF-α -238 A/G polymorphism and periodontitis. The meta-analysis indicated an association of the IL-6 -174 G/C polymorphisms with periodontitis in Brazilian populations (OR for GG+GC=2.394, 95% CI=1.081-5.302, p=0.031). Stratification by ethnicity and disease type indicated an association between the IL-6 -572 G allele and chronic periodontitis (OR=1.585, 95 % CI=1.030-2.439, p=0.036), and periodontitis in Europeans (OR=2.118, 95% CI=1.254-3.577, p=0.005). This meta-analysis demonstrates that the TNF-α -308 A/G polymorphism confers susceptibility to periodontitis in Brazilian, Asian and Turkish populations. The IL-6 -174 G/C polymorphism may confer susceptibility to periodontitis in Brazilians, and the IL-6 -572 G/C polymorphism may be associated with susceptibility to periodontitis in Europeans, and chronic periodontitis.
本研究旨在探讨肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）启动子多态性是否与不同种族人群的牙周炎易感性相关。使用 PubMed 和 Embase 进行文献检索，并对鉴定出的研究进行荟萃分析，以探讨 TNF-α-308A/G、-238A/G、IL-6 启动子-174G/C 和-572G/C 多态性与牙周炎之间的关联。荟萃分析纳入了 17 项 TNF-α-308A/G 多态性的比较研究和 3 项 TNF-α-238A/G 多态性的研究。我们的荟萃分析还考虑了 16 项单独的 IL-6-174G/C 多态性研究和 10 项 IL-6-572G/C 多态性研究。按种族分层的分析表明，TNF-α-308A 等位基因与巴西、亚洲和土耳其人群的牙周炎相关（OR=0.637，95%CI=0.447-0.907，p=0.013；OR=0.403，95%CI=0.204-0.707，p=0.009；OR=1.818，95%CI=1.036-3.189，p=0.037）。荟萃分析显示 TNF-α-238A/G 多态性与牙周炎无关。荟萃分析表明，IL-6-174G/C 多态性与巴西人群的牙周炎相关（OR 为 GG+GC=2.394，95%CI=1.081-5.302，p=0.031）。按种族和疾病类型分层表明，IL-6-572G 等位基因与慢性牙周炎（OR=1.585，95%CI=1.030-2.439，p=0.036）和欧洲人群的牙周炎（OR=2.118，95%CI=1.254-3.577，p=0.005）相关。本荟萃分析表明，TNF-α-308A/G 多态性使巴西、亚洲和土耳其人群易患牙周炎。IL-6-174G/C 多态性可能使巴西人易患牙周炎，IL-6-572G/C 多态性可能与欧洲人易患牙周炎和慢性牙周炎相关。
