Tsujimoto Hiroyuki, Takamori Hideki, Tsuji Misaki, Hayashi Maho, Ikeda Junki, Orikasa Taichi, Torii Hiroko, Ozamoto Yuki, Suzuki Shuko, Morita Shinichiro, Ikada Yoshito, Hagiwara Akeo
Division of Medical Life System, Department of Life and Medical Science, Doshisha University, 1-3 Tatara-Miyakodani, Kyotanabe, Kyoto, 610-0321, Japan,
Surg Today. 2014 Feb;44(2):391-4. doi: 10.1007/s00595-013-0608-3. Epub 2013 May 9.
To overcome the problems associated with sheet- or film-type anti-adhesive materials, we developed a new type of anti-adhesive material, gelatin flakes. We made two types of gelatin flakes with or without thermal cross-linking, and preliminarily examined their basic properties and the anti-adhesive efficacy using a rodent adhesion model. Both types of the gelatin flakes rapidly turned into gel and tightly attached the injured surfaces, absorbing the moisture and blood, when applied onto the abraded sites of rats. In addition, these flakes could be sprayed into the desired area by compressed air through a device with a long, thin tube, which could be used in laparoscopic surgery. The anti-adhesive effects of both types of gelatin flakes were similar, and both types were significantly superior compared to the non-treated group. Although further investigations are necessary, the gelatin flakes have unique and useful properties and satisfactory anti-adhesive effects, which indicate that they may be applicable in laparoscopic surgery.
为克服与片状或薄膜状抗粘连材料相关的问题，我们研发了一种新型抗粘连材料——明胶薄片。我们制备了两种明胶薄片，一种经过热交联，另一种未经过热交联，并使用啮齿动物粘连模型初步研究了它们的基本特性和抗粘连效果。当将这两种明胶薄片应用于大鼠的擦伤部位时，它们都会迅速变成凝胶并紧密附着在受伤表面，吸收水分和血液。此外，通过带有细长管的装置利用压缩空气可将这些薄片喷到所需区域，该装置可用于腹腔镜手术。两种明胶薄片的抗粘连效果相似，且与未处理组相比均显著更优。尽管还需要进一步研究，但明胶薄片具有独特且有用的特性以及令人满意的抗粘连效果，这表明它们可能适用于腹腔镜手术。
