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本文引用的文献

1
Carbapenem resistance in Enterobacteriaceae: here is the storm!肠杆菌科的碳青霉烯类耐药性：风暴将至！
Trends Mol Med. 2012 May;18(5):263-72. doi: 10.1016/j.molmed.2012.03.003. Epub 2012 Apr 3.
2
VIM-2 metallo-β-lactamase-producing Pseudomonas aeruginosa causing an outbreak in South Africa.在南非引发疫情的产VIM-2金属β-内酰胺酶的铜绿假单胞菌。
J Antimicrob Chemother. 2012 Jul;67(7):1797-8. doi: 10.1093/jac/dks100. Epub 2012 Mar 28.
3
Emergence of carbapenem-resistant non-baumannii species of Acinetobacter harboring a blaOXA-51-like gene that is intrinsic to A. baumannii.耐碳青霉烯类非鲍曼不动杆菌种的出现，这些菌株携带 blaOXA-51 样基因，该基因是鲍曼不动杆菌的固有基因。
Antimicrob Agents Chemother. 2012 Feb;56(2):1124-7. doi: 10.1128/AAC.00622-11. Epub 2011 Nov 14.
4
Nosocomial outbreak of imipenem-resistant Pseudomonas aeruginosa producing VIM-2 metallo-β-lactamase in a kidney transplantation unit.肾移植病房产 VIM-2 型金属β-内酰胺酶的耐亚胺培南铜绿假单胞菌医院感染暴发。
Diagn Pathol. 2011 Oct 28;6:106. doi: 10.1186/1746-1596-6-106.
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Genetic features of blaNDM-1-positive Enterobacteriaceae.blaNDM-1 阳性肠杆菌科的遗传特征。
Antimicrob Agents Chemother. 2011 Nov;55(11):5403-7. doi: 10.1128/AAC.00585-11. Epub 2011 Aug 22.
6
Status report on carbapenemases: challenges and prospects.碳青霉烯酶：挑战与展望的现状报告。
Expert Rev Anti Infect Ther. 2011 May;9(5):555-70. doi: 10.1586/eri.11.28.
7
Multiplex PCR for detection of acquired carbapenemase genes.多重 PCR 检测获得性碳青霉烯酶基因。
Diagn Microbiol Infect Dis. 2011 May;70(1):119-23. doi: 10.1016/j.diagmicrobio.2010.12.002. Epub 2011 Mar 12.
8
Emergence and Distribution of Plasmids Bearing the blaOXA-51-like gene with an upstream ISAba1 in carbapenem-resistant Acinetobacter baumannii isolates in Taiwan.台湾地区耐碳青霉烯鲍曼不动杆菌分离株中携带 blaOXA-51 样基因和上游 ISAba1 的质粒的出现和分布。
Antimicrob Agents Chemother. 2010 Nov;54(11):4575-81. doi: 10.1128/AAC.00764-10. Epub 2010 Aug 16.
9
Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands.荷兰一株阴沟肠杆菌临床分离株中整合子编码的金属β-内酰胺酶 DIM-1 的特性研究。
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10
KPC-producing extreme drug-resistant Klebsiella pneumoniae isolate from a patient with diabetes mellitus and chronic renal failure on hemodialysis in South Korea.从韩国一名患有糖尿病和慢性肾衰竭且正在接受血液透析的患者身上分离出的产KPC的极端耐药肺炎克雷伯菌菌株。
Antimicrob Agents Chemother. 2010 May;54(5):2278-9. doi: 10.1128/AAC.00011-10. Epub 2010 Mar 8.

从塞拉利昂医院肠杆菌科分离株中鉴定出 blaOXA-₅₁-like、blaOXA-₅₈、blaDIM-₁ 和 blaVIM 碳青霉烯酶基因。

Identification of blaOXA-₅₁-like, blaOXA-₅₈, blaDIM-₁, and blaVIM carbapenemase genes in hospital Enterobacteriaceae isolates from Sierra Leone.

机构信息

Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, District of Columbia, USA.

出版信息

J Clin Microbiol. 2013 Jul;51(7):2435-8. doi: 10.1128/JCM.00832-13. Epub 2013 May 8.

DOI:10.1128/JCM.00832-13
PMID:23658259
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3697688/
Abstract

We describe the results of a molecular epidemiological survey of 15 carbapenemase-encoding genes from a recent collection of clinical isolates from Mercy Hospital in Bo, Sierra Leone. The most salient findings revealed that (i) 60% of the isolates harbored multiple carbapenemase genes; (ii) the blaDIM-1 gene, which has previously only been reported in The Netherlands, is also circulating in this environment; and (iii) blaOXA-51-like and blaOXA-58 genes, which were thought to reside exclusively in Acinetobacter species, can also be found in members of the Enterobacteriaceae.

摘要

我们描述了对来自塞拉利昂博城 mercy 医院最近收集的临床分离株中 15 种碳青霉烯酶编码基因的分子流行病学调查结果。最显著的发现表明：（i）60%的分离株携带多种碳青霉烯酶基因；（ii）blaDIM-1 基因以前仅在荷兰报道过，也在这种环境中传播；（iii）blaOXA-51 样和 blaOXA-58 基因，以前认为仅存在于不动杆菌属物种中，也可以在肠杆菌科成员中发现。