Kolesnikova L I, Madaeva I M, Semenova N V, Vlasov B Ya, Grebenkina L A, Darenskaya M A, Dolgikh M I
Research Center of Family Health Protection and Human Reproduction Problems, Siberian Division of Russian Academy of Medical Sciences, Irkutsk, Russia.
Bull Exp Biol Med. 2013 Apr;154(6):731-3. doi: 10.1007/s10517-013-2041-4.
We studied the state of the LPO-antioxidant defense system in men aged from 46 to 55 years. The main group included patients with obstructive sleep breathing disorders. The state of the antioxidant defense system was assessed by measuring the blood levels of LPO substrates with conjugated double bonds, conjugated dienes, ketodienes and conjugated trienes, MDA, retinol, α-tocopherol, reduced and oxidized glutathione, SOD activity, and the level of total antioxidant activity of blood. Calculation of antioxidant potential helps to identify the processes of "oxidative stress" in the main group, which is a pathogenetic substantiation for including antioxidant drugs in the complex therapy of patients with OSBD.
我们研究了46至55岁男性的脂质过氧化-抗氧化防御系统状态。主要研究组包括患有阻塞性睡眠呼吸障碍的患者。通过测量血液中具有共轭双键的脂质过氧化底物、共轭二烯、酮二烯和共轭三烯、丙二醛、视黄醇、α-生育酚、还原型和氧化型谷胱甘肽、超氧化物歧化酶活性以及血液总抗氧化活性水平来评估抗氧化防御系统的状态。抗氧化潜力的计算有助于确定主要研究组中的“氧化应激”过程，这是在阻塞性睡眠呼吸障碍患者的综合治疗中纳入抗氧化药物的发病机制依据。
