Kolesnikova L I, Rychkova L V, Darenskaya M A, Grebenkina L A, Gavrilova O A, Zhdanova L V, Buldaeva E A, Kolesnikov S I
Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk.
Buryat State University, Ulan-Ude.
Vopr Pitan. 2018;87(5):13-19. doi: 10.24411/0042-8833-2018-10048. Epub 2018 Sep 13.
It is assumed that in the progression of obesity, complicated by fatty hepatosis in adolescents, a significant role is given to the reactions of oxidative stress with deficiency of antioxidant factors. However, an important factor that remains outside the field of view of researchers is the ethnicity of the patient, which is an important element in the development of a personalized approach in the treatment and prevention of diseases. In connection with this, the purpose of this study was to study the changes in the lipid peroxidation-antioxidant defense processes in adolescent Mongoloids with exogenously constitutional obesity complicated by fatty hepatosis. 18 adolescent boys with fatty hepatosis were examined on the background of exogenous-constitutional obesity of the first degree; 38 adolescent boys with exogenously constitutional obesity without changes in the liver and 37 practically healthy adolescents (control group). All subjects surveyed for ethnicity belonged to the Mongoloids. Spectrophotometric and fluorometric methods were used in the research. The results of the study indicated a high intensity of lipid peroxidation reactions in Mongoloid boys with obesity and fatty hepatosis relative to control values: an increase in blood plasma content of compounds with unsaturated double bonds (p<0.001), diene conjugates (p=0.0012), ketodienes and conjugated trienes (p<0.0001), in the absence of significant differences in the level of TBA-active products. Increased values of total antioxidant activity in blood plasma (p=0.0023) and erythrocyte superoxide dismutase activity (p=0.0072), decreased levels of fat-soluble vitamins in blood plasma [α-tocopherol (p<0.0001) and retinol (p=0.0011)] and oxidized form of glutathione in erythrocytes (p=0.0083) have been found. The pronounced insufficiency of fatsoluble vitamins - α-tocopherol and retinol in patients of the main group was also noted in comparison with patients without morphological changes in the liver. Thus, in teenage Mongoloids with exogenously constitutional obesity and fatty hepatosis, it is possible to recommend antioxidant drugs in addition to basic metabolic therapy.
假设在青少年肥胖症进展过程中，若并发脂肪性肝病，氧化应激反应及抗氧化因子缺乏起着重要作用。然而，研究者视野之外的一个重要因素是患者的种族，这是疾病治疗和预防中个性化方法发展的一个重要元素。鉴于此，本研究的目的是研究患有外源性体质性肥胖并并发脂肪性肝病的青少年蒙古人种脂质过氧化 - 抗氧化防御过程的变化。对18名患有脂肪性肝病的青春期男孩进行了检查，其处于一度外源性体质性肥胖背景下；38名患有外源性体质性肥胖但肝脏无变化的青春期男孩以及37名实际健康的青少年（对照组）。所有接受种族调查的受试者均属于蒙古人种。研究中使用了分光光度法和荧光法。研究结果表明，与对照组相比，患有肥胖症和脂肪性肝病的蒙古人种男孩脂质过氧化反应强度较高：血浆中具有不饱和双键的化合物含量增加（p<0.001）、二烯共轭物（p = 0.0012）、酮二烯和共轭三烯（p<0.0001），而TBA活性产物水平无显著差异。发现血浆中总抗氧化活性值增加（p = 0.0023）以及红细胞超氧化物歧化酶活性增加（p = 0.0072），血浆中脂溶性维生素水平降低[α - 生育酚（p<0.0001）和视黄醇（p = 0.0011）]以及红细胞中谷胱甘肽氧化形式降低（p = 0.0083）。与肝脏无形态学变化的患者相比，主要组患者中脂溶性维生素 - α - 生育酚和视黄醇明显不足也被注意到。因此，对于患有外源性体质性肥胖和脂肪性肝病的青少年蒙古人种，除基础代谢治疗外，推荐使用抗氧化药物。
