Kolesnikova L I, Madaeva I M, Semenova N V, Solodova L A, Grebenkina E I
Klin Lab Diagn. 2014 Dec;59(12):29-32.
The article presents results of individual evaluation of coefficient of oxidative stress as an integral indicator of balance of the system "lipids peroxidation-antioxidant defense" in women with sleep disturbances in post menopause conditions. The condition of the system "lipids peroxidation-antioxidant defense" was evaluated using analysis of content of substrates of oxidation of processes of lipid peroxidation with conjugated double bonds, diene conjugates, ketodienes and conjugated trienes, TBC-active products of retinol α-tokoferol, reduced and oxidized glutathione, activity of superoxiddismutase in blood. The application of coefficient of oxidative stress permitted to demonstrate differences in processes of lipids peroxidation in women with the same diagnosis and use it as a justification of individual approach under prescription of antioxidant therapy.
本文介绍了对氧化应激系数进行个体评估的结果，该系数是绝经后睡眠障碍女性“脂质过氧化-抗氧化防御”系统平衡的综合指标。通过分析脂质过氧化过程中具有共轭双键的氧化底物、二烯共轭物、酮二烯和共轭三烯的含量、视黄醇α-生育酚的TBC活性产物、还原型和氧化型谷胱甘肽以及血液中超氧化物歧化酶的活性，评估了“脂质过氧化-抗氧化防御”系统的状况。氧化应激系数的应用能够证明相同诊断的女性在脂质过氧化过程中存在差异，并将其作为抗氧化治疗处方中采用个体化方法的依据。
