Istanbul Technical University, Informatics Institute, Computational Science and Engineering, Ayazaga Kampusu, Maslak 34469, Istanbul, Turkey.
Comput Biol Med. 2013 Jul;43(6):717-28. doi: 10.1016/j.compbiomed.2013.02.014. Epub 2013 Apr 18.
In this study the biomechanical characteristics of a realistic carotid artery [3] are studied numerically using different inlet velocity profiles. Several experimental data measured [32] at the common carotid artery are used as inlet boundary conditions. Computation domain is generated using computed tomography (CT) data of a real patient. Three dimensional (3D) transient NS equations are solved, in this actual domain, using the proposed boundary conditions. Effects of different input conditions on the results of simulation are discussed. Main parameters such as velocity profiles, wall shear stress (WSS) and pressure distributions are investigated at the critical parts of the carotid artery such as bifurcation and sinusoidal enlargement regions. Results show that the input boundary conditions and slope/curvature discontinuities in the realistic geometry have strong relationship with the velocity, pressure and WSS distributions as expected. The most important conclusion obtained from our model is the existence of negative relation between velocity at several inner points of the internal carotid artery and velocity at the inlet of the common carotid artery.
在这项研究中，使用不同的入口速度剖面对真实颈动脉的生物力学特性进行了数值研究。使用了在颈总动脉处测量的一些实验数据[32]作为入口边界条件。计算域是使用真实患者的计算机断层扫描（CT）数据生成的。在实际域中，使用所提出的边界条件来求解三维（3D）瞬态 NS 方程。讨论了不同输入条件对模拟结果的影响。在颈动脉的关键部位，如分叉和窦状扩张区域，研究了速度剖面、壁面剪切应力（WSS）和压力分布等主要参数。结果表明，输入边界条件和真实几何形状中的斜率/曲率不连续性与速度、压力和 WSS 分布之间存在预期的强关系。从我们的模型中得到的最重要的结论是，颈内动脉的几个内部点的速度与颈总动脉入口的速度之间存在负相关关系。
