Department of Food Science and Nutrition, Pusan National University, Busan 609-735, Republic of Korea.
Eur J Pharmacol. 2013 Jul 15;712(1-3):48-52. doi: 10.1016/j.ejphar.2013.04.047. Epub 2013 May 10.
This study was designed to investigate whether daidzein inhibits α-glucosidase and α-amylase activities and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice. Daidzein showed prominent inhibitory effects against α-glucosidase and α-amylase. The IC50 values of daidzein against α-glucosidase and α-amylase were 0.048 and 0.301 mmol, respectively, which showed that daidzein was more effective than acarbose. The increase in postprandial blood glucose levels was more significantly suppressed in the daidzein-administered group than in the water group of both streptozotocin-induced diabetic and normal mice. Moreover, the area under the curve was significantly lowered following daidzein administration (2043 versus 2475 mmol min l) in the streptozotocin-induced diabetic mice. These results indicated that daidzein may be a potent α-glucosidase inhibitor and suppress the postprandial hyperglycemia caused by starch.
本研究旨在探讨大豆苷元是否抑制α-葡萄糖苷酶和α-淀粉酶活性，以及减轻链脲佐菌素诱导的糖尿病小鼠的餐后高血糖。大豆苷元对α-葡萄糖苷酶和α-淀粉酶表现出显著的抑制作用。大豆苷元对α-葡萄糖苷酶和α-淀粉酶的 IC50 值分别为 0.048 和 0.301mmol，表明大豆苷元比阿卡波糖更有效。与水组相比，给予大豆苷元的糖尿病小鼠和正常小鼠的餐后血糖水平升高明显受到抑制。此外，在链脲佐菌素诱导的糖尿病小鼠中，给予大豆苷元后曲线下面积显著降低（2043 与 2475mmolminl）。这些结果表明，大豆苷元可能是一种有效的α-葡萄糖苷酶抑制剂，可抑制淀粉引起的餐后高血糖。
