Matuszewski Łukasz, Olchowik Grażyna, Mazurkiewicz Tomasz, Kowalczyk Bartłomiej, Zdrojewska Agata, Matuszewska Anna, Ciszewski Andrzej, Gospodarek Małgorzata, Morawik Iwona
Pediatric Orthopedic and Rehabilitation Clinic, Medical University of Lublin, Ul. Chodźki 2, 21-093, Lublin, Poland,
Eur J Orthop Surg Traumatol. 2014 May;24(4):435-41. doi: 10.1007/s00590-013-1230-1. Epub 2013 May 14.
Bisphosphonates (BPs) are well-known substances with very efficient antiresorptive properties. Their beneficial actions are useful not only in achieving better bone mineral density but also in improving bone microarchitecture, strength and, consequently, its quality. Surgical cement, being a polymer composite, is required to be highly biocompatible and biotolerant. The goal of the presented study was to assess whether the enrichment of cement with pamidronate has changed its biomechanical properties. We compared the biomechanical parameters of clean bone cement and BP-enriched bone cement, which were both used formerly in our rat models. Biomechanical properties of BP-enriched bone cement are defined by two basic terms: stress and strain, which are caused by the influence of external force. In the investigatory process of the bone's biomechanical parameters, the compressive test and the three-point flexural tests were used. During the three-point flexural investigation, the sample was supported at both ends and loaded in the middle, resulting in a flexure. After a specific range of flexure, the sample was fractured. In obtained results, there were no significant differences in the values of the stress determined at the point of maximal load and the energy stored in the samples for proportional stress-strain limit (elastic region). There were also no significant differences in the density of the samples. The study shows that the enrichment of bisphosphonates causes yielding of the bone cement material. In the presented data, we conclude that use of pamidronate implanted in bone cement did not have a detrimental effect on its biomechanical properties. Therefore, the obtained results encouraged us to perform further in vivo experiments which assess the biomechanical properties of bones implanted with BP-enriched bone cement.
双膦酸盐（BPs）是具有高效抗吸收特性的知名物质。它们的有益作用不仅有助于提高骨矿物质密度，还能改善骨微结构、强度，进而提升骨质量。外科骨水泥作为一种聚合物复合材料，需要具有高度的生物相容性和生物耐受性。本研究的目的是评估用帕米膦酸盐富集骨水泥是否改变了其生物力学性能。我们比较了清洁骨水泥和富含双膦酸盐的骨水泥的生物力学参数，这两种骨水泥此前都用于我们的大鼠模型。富含双膦酸盐的骨水泥的生物力学性能由两个基本术语定义：应力和应变，它们是由外力影响引起的。在研究骨生物力学参数的过程中，使用了压缩试验和三点弯曲试验。在三点弯曲研究中，样品两端支撑，中间加载，从而产生弯曲。在特定的弯曲范围内后，样品断裂。在获得的结果中，在最大载荷点测定的应力值以及在比例应力 - 应变极限（弹性区域）下样品中储存的能量方面没有显著差异。样品的密度也没有显著差异。该研究表明，双膦酸盐的富集导致骨水泥材料的屈服。在给出的数据中，我们得出结论，植入骨水泥中的帕米膦酸盐对其生物力学性能没有不利影响。因此，获得的结果鼓励我们进行进一步的体内实验，以评估植入富含双膦酸盐骨水泥的骨骼的生物力学性能。
