Dubreuil L, Derriennic M, Sedallian A
Faculté de Pharmacie, Lille.
Pathol Biol (Paris). 1990 May;38(5):343-6.
The in vitro activity of a new cephalosporin (CPX) was assessed against 260 strains of anaerobic bacteria. A comparison was done with two other oral cephalosporins cefaclor (CFA) and cefuroxime (CXM). MICs were determined by an agar-dilution method on wilkins chalgren agar. The three antibiotics had little activity against Bacteroïdes fragilis group. Cefpodoxime was more active than the two other cephalosporins against Fusobacterium and Bacteroïdes spp. At 4 mg/l concentration the percentages of susceptibility were respectively CFA 8% CXM 11% for all the Gram negative bacilli. Inversely, a better activity was detected against Gram positive anaerobes; the three cephalosporins inhibiting respectively CFA 65% CXM 75% CFX 46% of 94 tested strains. All Veillonella spp. and Propionibacteria were inhibited by cefpodoxime 4 mg/l. The activity of the three cephalosporins were similar weak against Gram negative anaerobes but greater against Gram positive strict anaerobes.
评估了一种新型头孢菌素（CPX）对260株厌氧菌的体外活性。并与另外两种口服头孢菌素头孢克洛（CFA）和头孢呋辛（CXM）进行了比较。采用琼脂稀释法在威尔金斯查尔格伦琼脂上测定最低抑菌浓度（MIC）。这三种抗生素对脆弱拟杆菌群活性较弱。头孢泊肟对梭杆菌属和拟杆菌属的活性比另外两种头孢菌素更强。在4mg/l浓度下，所有革兰氏阴性杆菌的药敏率分别为：CFA 8%，CXM 11%。相反，对革兰氏阳性厌氧菌检测到更好的活性；三种头孢菌素分别抑制了94株受试菌株中的65%（CFA）、75%（CXM）、46%（CFX）。所有韦荣球菌属和丙酸杆菌属在4mg/l头孢泊肟作用下均被抑制。这三种头孢菌素对革兰氏阴性厌氧菌的活性相似较弱，但对革兰氏阳性严格厌氧菌的活性更强。
