Knapp C C, Washington J A
Department of Microbiology, Cleveland Clinic Foundation, Ohio 44106.
Antimicrob Agents Chemother. 1988 Jan;32(1):131-3. doi: 10.1128/AAC.32.1.131.
The in vitro activity of LY163892, a synthetic oral cephalosporin, was compared with those of cefaclor and cefuroxime against 1,193 clinical isolates. MIC ranges and MICs for 50 and 90% of isolates of the three cephalosporins were comparable. The activities of LY163892 and cefaclor were, however, highly inoculum dependent against beta-lactamase-positive Haemophilus influenzae and Staphylococcus aureus; that of cefuroxime was not. LY163892 and cefuroxime appeared stable in microdilution trays stored at 5 and -20 degrees C for 5 weeks, in contrast to cefaclor which remained stable for more than a week only at -5 degrees C.
将合成口服头孢菌素LY163892的体外活性与头孢克洛和头孢呋辛针对1193株临床分离株的活性进行了比较。三种头孢菌素的MIC范围以及50%和90%分离株的MIC相当。然而，LY163892和头孢克洛对β-内酰胺酶阳性的流感嗜血杆菌和金黄色葡萄球菌的活性高度依赖接种量；而头孢呋辛则不然。与头孢克洛仅在-5℃下能稳定一周以上不同，LY163892和头孢呋辛在5℃和-20℃储存5周的微量稀释板中似乎稳定。
