In vitro activities of LY163892, cefaclor, and cefuroxime.
作者信息
Knapp C C, Washington J A
机构信息
Department of Microbiology, Cleveland Clinic Foundation, Ohio 44106.
出版信息
Antimicrob Agents Chemother. 1988 Jan;32(1):131-3. doi: 10.1128/AAC.32.1.131.
Abstract
The in vitro activity of LY163892, a synthetic oral cephalosporin, was compared with those of cefaclor and cefuroxime against 1,193 clinical isolates. MIC ranges and MICs for 50 and 90% of isolates of the three cephalosporins were comparable. The activities of LY163892 and cefaclor were, however, highly inoculum dependent against beta-lactamase-positive Haemophilus influenzae and Staphylococcus aureus; that of cefuroxime was not. LY163892 and cefuroxime appeared stable in microdilution trays stored at 5 and -20 degrees C for 5 weeks, in contrast to cefaclor which remained stable for more than a week only at -5 degrees C.
摘要
相似文献
1
In vitro activities of LY163892, cefaclor, and cefuroxime.
Antimicrob Agents Chemother. 1988 Jan;32(1):131-3. doi: 10.1128/AAC.32.1.131.
2
[Comparative antibacterial activity of cefpodoxime, cefuroxime and cefaclor against strict anaerobic bacteria].
Pathol Biol (Paris). 1990 May;38(5):343-6.
3
In vitro activity and beta-lactamase stability of LY163892.
Eur J Clin Microbiol Infect Dis. 1988 Aug;7(4):549-51. doi: 10.1007/BF01962613.
4
Comparative in-vitro activity of a new oral carbacephem, LY163892.
J Antimicrob Chemother. 1988 Oct;22(4):445-56. doi: 10.1093/jac/22.4.445.
5
Antimicrobial activities and susceptibility testing considerations of ampicillin, cephalothin, cefaclor, and cefuroxime against invasive isolates of Haemophilus influenzae.
Chemotherapy. 1989;35(2):88-94. doi: 10.1159/000238653.
6
Influence of storage and susceptibility test conditions on stability and activity of LY163892 and four other cephalosporins.
Antimicrob Agents Chemother. 1988 Oct;32(10):1477-80. doi: 10.1128/AAC.32.10.1477.
7
Pharmacodynamic activity of five oral cephalosporins against Haemophilus influenzae.
Pharmacotherapy. 1997 Mar-Apr;17(2):235-41.
8
Antimicrobial activity of LY163892, an orally administered 1-carbacephem.
J Antimicrob Chemother. 1988 Sep;22(3):315-20. doi: 10.1093/jac/22.3.315.
9
In-vitro activity and beta-lactamase stability of LY163892.
J Antimicrob Chemother. 1988 Aug;22(2):155-65. doi: 10.1093/jac/22.2.155.
10
In-vitro activity of cefaclor, cephalexin and ampicillin against 2458 clinical isolates of Haemophilus influenzae.
J Antimicrob Chemother. 1988 Jan;21(1):27-31. doi: 10.1093/jac/21.1.27.
引用本文的文献
1
Cefuroxime axetil. A review of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy.
Drugs. 1996 Jul;52(1):125-58. doi: 10.2165/00003495-199652010-00009.
2
Prophylaxis with oral cefadroxil versus intravenous cefuroxime in trochanteric fracture surgery. A clinical multicentre study.
Arch Orthop Trauma Surg. 1995;114(6):303-7. doi: 10.1007/BF00448952.
3
Effectiveness of short-course therapy (5 days) with cefuroxime axetil in treatment of secondary bacterial infections of acute bronchitis.
Antimicrob Agents Chemother. 1995 Nov;39(11):2528-34. doi: 10.1128/AAC.39.11.2528.
4
Loracarbef. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic efficacy.
Drugs. 1993 May;45(5):716-36. doi: 10.2165/00003495-199345050-00008.
5
Pharmacokinetics of LY163892 in infants and children.
Antimicrob Agents Chemother. 1988 Nov;32(11):1738-9. doi: 10.1128/AAC.32.11.1738.
6
Influence of storage and susceptibility test conditions on stability and activity of LY163892 and four other cephalosporins.
Antimicrob Agents Chemother. 1988 Oct;32(10):1477-80. doi: 10.1128/AAC.32.10.1477.
7
In vitro activity and beta-lactamase stability of LY163892.
Eur J Clin Microbiol Infect Dis. 1988 Aug;7(4):549-51. doi: 10.1007/BF01962613.
8
Comparative in vitro activities of several new fluoroquinolones and beta-lactam antimicrobial agents against community isolates of Streptococcus pneumoniae.
Antimicrob Agents Chemother. 1990 Mar;34(3):467-9. doi: 10.1128/AAC.34.3.467.
9
Loracarbef versus cefaclor in the treatment of urinary tract infections in women.
Antimicrob Agents Chemother. 1991 Apr;35(4):750-2. doi: 10.1128/AAC.35.4.750.
10
Bactericidal titers of loracarbef (LY 163892) in serum and killing rates in volunteers receiving 400 versus 200 milligrams.
Antimicrob Agents Chemother. 1992 Mar;36(3):521-6. doi: 10.1128/AAC.36.3.521.
本文引用的文献
1
Pharmacology of Cefuroxime as the 1-acetoxyethyl ester in volunteers.
Antimicrob Agents Chemother. 1984 Jan;25(1):78-82. doi: 10.1128/AAC.25.1.78.
2
Influence of beta-lactamase-producing strains of Branhamella catarrhalis and Haemophilus influenzae on certain beta-lactam antibiotics.
J Antimicrob Chemother. 1983 Sep;12(3):269-71. doi: 10.1093/jac/12.3.269.
3
Cefuroxime - a new cephalosporin antibiotic.
J Antibiot (Tokyo). 1976 Jan;29(1):29-37. doi: 10.7164/antibiotics.29.29.
4
Cefaclor: in vitro spectrum of activity and beta-lactamase stability.
Antimicrob Agents Chemother. 1978 Apr;13(4):584-8. doi: 10.1128/AAC.13.4.584.
5
Comparative beta-lactamase resistance and antistaphylococcal activities of parenterally and orally administered cephalosporins.
J Infect Dis. 1978 Apr;137(4):490-3. doi: 10.1093/infdis/137.4.490.
6
Comparison of in vitro activity of cephalexin, cephradine, and cefaclor.
Antimicrob Agents Chemother. 1977 Mar;11(3):470-4. doi: 10.1128/AAC.11.3.470.
7
Cefuroxime, a beta-lactamase-resistant cephalosporin with a broad spectrum of gram-positive and -negative activity.
Antimicrob Agents Chemother. 1978 Apr;13(4):657-64. doi: 10.1128/AAC.13.4.657.
8
Stability and blood level determinations of cefaclor, a new oral cephalosporin antibiotic.
Antimicrob Agents Chemother. 1978 Jan;13(1):49-52. doi: 10.1128/AAC.13.1.49.
Zotero 插件