Miller James J, Hui Susanta K, Jackson George S, Clark Sara P, Einstein Jane, Weaver Connie M, Bhattacharyya Maryka H
Argonne National Laboratory, 9700 South Cass Avenue, Lemont, IL 60439, USA.
Appl Radiat Isot. 2013 Aug;78:57-61. doi: 10.1016/j.apradiso.2013.04.012. Epub 2013 Apr 17.
Calcium oxalate precipitation is the first step in preparation of biological samples for (41)Ca analysis by accelerator mass spectrometry. A simplified protocol for large-volume human urine samples was characterized, with statistically significant increases in ion current and decreases in interference. This large-volume assay minimizes cost and effort and maximizes time after (41)Ca administration during which human samples, collected over a lifetime, provide (41)Ca:Ca ratios that are significantly above background.
草酸钙沉淀是通过加速器质谱法对生物样品进行⁴¹Ca分析制备过程的第一步。我们对一种用于大量人类尿液样本的简化方案进行了表征，结果显示离子电流有统计学意义的增加，干扰减少。这种大量样本检测方法将成本和工作量降至最低，并在注入⁴¹Ca后的时间内实现最大化，在此期间，收集的一生的人类样本所提供的⁴¹Ca:Ca比值显著高于背景值。
