用于生物医学研究的加速器质谱分析法

Accelerator mass spectrometry for biomedical research.

作者信息

Brown Karen, Dingley Karen H, Turteltaub Kenneth W

机构信息

Lawrence Livermore National Laboratory, Livermore, California, USA.

出版信息

Methods Enzymol. 2005;402:423-43. doi: 10.1016/S0076-6879(05)02014-8.

DOI:10.1016/S0076-6879(05)02014-8

PMID:16401518

Abstract

Accelerator mass spectrometry (AMS) is the most sensitive method for detecting and quantifying rare long-lived isotopes with high precision. In this chapter, we review the principles underlying AMS-based biomedical studies, focusing on important practical considerations and experimental procedures needed for the detection and quantitation of (14)C- and (3)H-labeled compounds in various experiment types.

摘要

加速器质谱法（AMS）是检测和高精度定量稀有长寿命同位素最灵敏的方法。在本章中，我们回顾基于AMS的生物医学研究的基本原理，重点关注各种实验类型中检测和定量（14）C和（3）H标记化合物所需的重要实际注意事项和实验程序。