Hu Mei-Hua, Huang Go-Shine, Wu Chang-Teng, Lin Jainn-Jim, Hsia Shao-Hsuan, Wang Huei-Shyong, Lin Kuang-Lin
1Department of Pediatrics, Chang Gung Memorial Hospital, Keelung and Chang Gung University College of Medicine, Taoyuan, Taiwan.
J Child Neurol. 2014 Feb;29(2):182-6. doi: 10.1177/0883073813488829. Epub 2013 May 14.
We investigated the plasma cytokine profiles of children with febrile seizures or severe acute encephalitis using multiplex cytometry to evaluate the role of cytokines in these diseases. Interleukin-6, -10, -12p70, -17A, -2, -4, -5, -9, -13, -22, and -1β, interferon-γ, and tumor necrosis factor-α were measured in the plasma from children with febrile seizures (n = 9) or severe acute encephalitis (n = 21). In multivariate analysis, interleukin-6 was significantly increased in the plasma of the febrile seizure patients compared to those with severe acute encephalitis, suggesting that interleukin-6 is activated during the acute stage of a febrile seizure. A lower plasma interleukin-6 concentration was significantly associated with severe acute encephalitis. The cytokine network may be deregulated in severe acute encephalitis via the persistence of an uncontrolled inflammatory state in the brain.
我们使用多重细胞术研究了热性惊厥或重症急性脑炎患儿的血浆细胞因子谱，以评估细胞因子在这些疾病中的作用。检测了9例热性惊厥患儿和21例重症急性脑炎患儿血浆中的白细胞介素-6、-10、-12p70、-17A、-2、-4、-5、-9、-13、-22和-1β、干扰素-γ以及肿瘤坏死因子-α。在多变量分析中，与重症急性脑炎患儿相比，热性惊厥患儿血浆中的白细胞介素-6显著升高，提示白细胞介素-6在热性惊厥急性期被激活。较低的血浆白细胞介素-6浓度与重症急性脑炎显著相关。重症急性脑炎中细胞因子网络可能因大脑中不受控制的炎症状态持续存在而失调。
