School of Population and Public Health, University of British Columbia Vancouver, British Columbia, Canada.
BMJ Open. 2013 May 14;3(5):e002624. doi: 10.1136/bmjopen-2013-002624.
Our objective was to determine the relationship between osteoarthritis (OA) and heart diseases (myocardial infarction (MI), angina, congestive heart failure (CHF)) and stroke using population-based survey data.
Cross-sectional study.
Canadian Community Health Survey (CCHS).
Adult participants in the CCHS cycles 1.1, 2.1 and 3.1 were included. CCHS provides nationally representative data on health determinants, health status and health system utilisation. We have identified 40 817 self-reported OA subjects and selected 1:1 matched non-OA respondents by age, sex and CCHS cycles.
Self-reported heart disease was the primary outcome and MI, angina, CHF and stroke were considered as secondary outcomes. Multivariable logistic regression models were used to estimate the ORs after adjusting for sociodemographic status, obesity, physical activity, smoking status, fruit and vegetable consumption, medication use, diabetes, hypertension and chronic obstructive pulmonary disease.
The mean age of OA cases was 66 years and 71.6% were women. OA exhibited increased odds of prevalent heart disease, and adjusted overall OR (95% CI) was 1.45 (1.36 to 1.54), 1.35 (1.21 to 1.50) among men and 1.51 (1.39 to 1.64) among women with OA. OA showed increased ORs for angina and CHF in both men and women, and for MI in women. ORs (95% CI) for men and women, respectively, were 1.08 (0.91 to 1.28) and 1.49 (1.28 to 1.75) for MI, 1.76 (1.43 to 2.17) and 1.84 (1.59 to 2.14) for angina, 1.50 (1.13 to 1.97) and 1.81 (1.49 to 2.21) for CHF, and 1.08 (0.83 to 1.40) and 1.13 (0.93 to 1.37) for stroke.
Prevalent OA was associated with self-reported heart disease, particularly angina, and CHF in both men and women, after controlling for established risk factors for these conditions. This study provides a rationale for further investigation of the association between OA and heart disease in longitudinal studies for investigating possible biological and behavioural mechanisms.
本研究旨在利用基于人群的调查数据，确定骨关节炎（OA）与心脏病（心肌梗死（MI）、心绞痛、充血性心力衰竭（CHF））和中风之间的关系。
横断面研究。
加拿大社区健康调查（CCHS）。
纳入 CCHS 周期 1.1、2.1 和 3.1 中的成年参与者。CCHS 提供了健康决定因素、健康状况和卫生系统利用情况的全国代表性数据。我们确定了 40817 例自报 OA 患者，并按年龄、性别和 CCHS 周期 1:1 匹配非 OA 应答者。
自报心脏病是主要结局，MI、心绞痛、CHF 和中风被视为次要结局。在调整社会人口统计学状况、肥胖、身体活动、吸烟状况、水果和蔬菜摄入、药物使用、糖尿病、高血压和慢性阻塞性肺疾病后，使用多变量逻辑回归模型估计比值比（OR）。
OA 病例的平均年龄为 66 岁，71.6%为女性。OA 患者患常见心脏病的几率增加，调整后的总体 OR（95%CI）为 1.45（1.36 至 1.54）、男性为 1.35（1.21 至 1.50），女性为 1.51（1.39 至 1.64）。OA 在男性和女性中均与心绞痛和 CHF 的 OR 增加，在女性中与 MI 的 OR 增加。男性和女性的 OR（95%CI）分别为 1.08（0.91 至 1.28）和 1.49（1.28 至 1.75）用于 MI，1.76（1.43 至 2.17）和 1.84（1.59 至 2.14）用于心绞痛，1.50（1.13 至 1.97）和 1.81（1.49 至 2.21）用于 CHF，1.08（0.83 至 1.40）和 1.13（0.93 至 1.37）用于中风。
在控制这些疾病的既定危险因素后，现患 OA 与男性和女性自报心脏病（特别是心绞痛和 CHF）相关。本研究为进一步研究 OA 与心脏病之间的关联提供了依据，以调查可能的生物学和行为机制。
