Shukla Rushikesh, Singh Shailja, Kamath Shruthi, Shah Urmil, Patel Siddhi, Kherajani Krish, Gupta Ananya, Shaw Priya, Unnithan Vishnu, Kaithathara Sharel, Gharde Pankaj
Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Medicine, Kasturba Medical College, Mangalore, Mangalore, IND.
Cureus. 2024 Apr 17;16(4):e58502. doi: 10.7759/cureus.58502. eCollection 2024 Apr.
Osteoarthritis (OA) and diabetes mellitus (DM) have long-term deleterious chronic effects and are among the most prevalent chronic disorders. DM and its associated factors, such as hyperglycemia, have a significant contribution to the pathophysiology of OA, particularly in post-menopausal women. Women who have uncontrolled diabetes (DM) are more prone to develop osteoarthritis (OA), which may be exacerbated by poor glycemic control. Furthermore, this category of female patients with DM has an increased risk of developing fractures, even in those with initially normal bone density scores, further illustrating the correlation between DM and bone health. Additionally, multiple risk factors, including obesity, metabolic syndrome, hypertension, estrogen-based hormone therapy, and hyperuricemia, in menopausal women can lead to the development and exacerbation of OA. It is discovered that these variables have a direct or indirect impact, frequently causing inflammation and hormonal changes, which contribute to the intricate interaction between DM and OA. The management of OA and DM in women thus calls for a multi-faceted management plan including glycemic control, weight control, exercise, and specialized pain management methods catering to the specific requirements of the patients. Regularly screening for OA should be implemented for menopausal women with DM and utmost care should be provided by healthcare professionals. Regular monitoring of joint health and early management, encouraging interdisciplinary cooperation, putting preventative measures into place, and creating individualized treatment programs are essential. A thorough understanding of the link between DM and OA will ultimately lead to improved health outcomes and a better future for these individuals.
骨关节炎（OA）和糖尿病（DM）具有长期有害的慢性影响，是最常见的慢性疾病之一。糖尿病及其相关因素，如高血糖，对骨关节炎的病理生理学有重大影响，尤其是在绝经后女性中。患有未控制糖尿病（DM）的女性更容易患骨关节炎（OA），血糖控制不佳可能会加剧这种情况。此外，这类患有糖尿病的女性患者发生骨折的风险增加，即使是那些初始骨密度评分正常的患者也是如此，这进一步说明了糖尿病与骨骼健康之间的相关性。此外，绝经后女性中的多种风险因素，包括肥胖、代谢综合征、高血压、雌激素类激素疗法和高尿酸血症，都可能导致骨关节炎的发生和加重。研究发现，这些变量具有直接或间接影响，常常引发炎症和激素变化，这促成了糖尿病与骨关节炎之间的复杂相互作用。因此，对女性骨关节炎和糖尿病的管理需要一个多方面的管理计划，包括血糖控制、体重控制、运动以及针对患者特定需求的专门疼痛管理方法。对于患有糖尿病的绝经后女性，应定期进行骨关节炎筛查，医疗保健专业人员应给予 utmost care。定期监测关节健康并进行早期管理、鼓励跨学科合作、采取预防措施以及制定个性化治疗方案至关重要。深入了解糖尿病与骨关节炎之间的联系最终将改善这些个体的健康状况并为他们带来更美好的未来。 （注：原文中“utmost care”表述有误，可能是“utmost”拼写错误，推测应为“utmost”，这里按“utmost care”字面意思翻译为“最大程度的 care”，结合语境理解为“给予最大程度的关注” ）
