绝经后女性血清降钙素基因相关肽、性激素、同型半胱氨酸与冠心病关系的研究
A Study of the Relationships between Serum Calcitonin Gene-Related Peptide, Sex Hormone, Homocysteine and Coronary Heart Disease in Postmenopausal Women.
作者信息
Zhen Wang, Jingxuan Guo, Xian Wang, Yiming Zhao, Lingfei Hou
机构信息
Department of Emergency, Peking University Third Hospital, Beijing, P. R. of China.
出版信息
Int J Biomed Sci. 2006 Feb;2(1):42-8.
OBJECTIVE
To investigate the relationships among serum calcitonin gene-related peptide (CGRP), homocysteine (Hcy), female hormone, and coronary arteriopathy in postmenopausal women.
METHOD
In a cross-sectional study, serum CGRP, estrodiol (E2), progesterone (P) and Hcy levels of 144 postmenopausal women with coronary heart disease (CHD) and non-coronary heart disease (NCHD) were measured.
RESULTS
The mean serum CGRP level was significantly lower in CHD patients than in NCHD subjects. The mean serum E2 and P level were significantly lower in CHD patients than in NCHD subjects. The mean serum Hcy level was significantly higher in CHD patients than in NCHD subjects. By multivariate logistic regression, the OR of high Hcy level ≥1, p<0.01, which suggests that Hcy is an independent risk factor in the development of coronary arteriopathy. The OR of CGRP, E2, and P are all≤1, indicating that CGRP, E2 and P are independent protective factor.
CONCLUSION
The results of our study show that Hcy is an independent risk factor in the development of arteriopathy. CGRP and endogenous E2 are independent protective factors in the development of coronary arteriopathy. There are no relationships between Hcy, CGRP, and endogenous E2.
目的
探讨绝经后女性血清降钙素基因相关肽（CGRP）、同型半胱氨酸（Hcy）、女性激素与冠状动脉病变之间的关系。
方法
在一项横断面研究中，对144例患有冠心病（CHD）和非冠心病（NCHD）的绝经后女性的血清CGRP、雌二醇（E2）、孕酮（P）和Hcy水平进行了测定。
结果
冠心病患者的血清CGRP平均水平显著低于非冠心病患者。冠心病患者的血清E2和P平均水平显著低于非冠心病患者。冠心病患者的血清Hcy平均水平显著高于非冠心病患者。通过多因素逻辑回归分析，高Hcy水平≥1时的比值比（OR），p<0.01，这表明Hcy是冠状动脉病变发生的独立危险因素。CGRP、E2和P的OR均≤1，表明CGRP、E2和P是独立的保护因素。
结论
我们的研究结果表明，Hcy是动脉病变发生的独立危险因素。CGRP和内源性E2是冠状动脉病变发生的独立保护因素。Hcy、CGRP和内源性E2之间无相关性。
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