Nokhodchi Ali, Talari Roya, Valizadeh Hadi, Jalali Mohammad Barzegar
Medway School of Pharmacy, the Universities of Kent and Greenwich, Central Ave., Chatham Maritime, ME4 4TB, Kent, UK;
Int J Biomed Sci. 2007 Sep;3(3):211-6.
The aim of this study was to prepare solid dispersions of chlordiazepoxide techniques to improve its dissolution rate. To this end, three techniques namely, two solvent methods and co-grinding technique were used. Solid dispersions of chlordiazepoxide in polyvinylpyrrolidone (PVP), Eudragit E100, Mannitol and Sorbitol with two different ratios of drug to carrier (5:5 and 1:9) were prepared. These solid dispersions were evaluated using dissolution tester to monitor dissolution behaviour and Fourier-transform infrared spectroscopy to investigate interaction between the drug and carriers in solid dispersion samples. Solid dispersion of chlordiazepoxide with all three carriers (PVP, mannitol and eudragit E) prepared by solvent method showed considerable increase in the dissolution rate of chlordiazepoxide in comparison with physical mixture and pure drug at different pH values. According to the results of this investigation cogrinding technique yields solid dispersions with a less improved dissolution rate than does the solvent deposition technique. Infrared studies showed no interaction between chlordiazepoxide and carriers in solid dispersions in solid state.
本研究的目的是采用技术制备氯氮卓的固体分散体，以提高其溶出速率。为此，使用了三种技术，即两种溶剂法和共研磨技术。制备了氯氮卓在聚乙烯吡咯烷酮（PVP）、丙烯酸树脂E100、甘露醇和山梨醇中的固体分散体，药物与载体的比例为两种不同比例（5:5和1:9）。使用溶出度测试仪评估这些固体分散体的溶出行为，并使用傅里叶变换红外光谱研究固体分散体样品中药物与载体之间的相互作用。通过溶剂法制备的氯氮卓与所有三种载体（PVP、甘露醇和丙烯酸树脂E）的固体分散体在不同pH值下，与物理混合物和纯药物相比，氯氮卓的溶出速率有显著提高。根据本研究结果，共研磨技术得到的固体分散体的溶出速率提高程度低于溶剂沉积技术。红外研究表明，氯氮卓与固态固体分散体中的载体之间没有相互作用。
