Gwarzo Muhammad Yalwa, Muhammad Surajo Al-Kassim
Department of Chemical Pathology, Bayero University Kano, PMB 3011, Kano, Nigeria;
Int J Biomed Sci. 2010 Dec;6(4):294-300.
This study looked at the profile of plasma extracellular superoxide dismutase (SOD3) activity, malondialdehyde (MDA) vis-à-vis that of CD4 counts in human immunodeficiency virus subjects in Kano State, Nigeria. The subjects for this study comprised twenty (20) non-HIV infected volunteers as control and one hundred (100) HIV infected subjects. Forty nine (49) infected patients have not been on treatment, while fifty one (51) were at various stages of treatment. There was a negative correlation between the serum malondialdehyde concentration and CD4 count (Pearson r=-0.68, p<0.01). There was also a negative correlation between serum malondialdehyde concentration and extracellular superoxide dismutase activity ((Pearson r=-0.71, p<0.01) and Vitamin A concentration (Pearson r=-0.75; p<0.01). Conversely a positive correlation was observed between the CD4 counts in HIV infected patients and activity of extracellular superoxide dismutase (Pearson r=0.86, p<0.01). Similarly there was a positive correlation between CD4 count and serum vitamin A concentration (Pearson r=0.89 p<0.01). The possibility remains for using these indicators to monitor HIV patients not eligible for therapy in resource constrained facilities of our rural areas.
本研究观察了尼日利亚卡诺州人类免疫缺陷病毒感染者血浆细胞外超氧化物歧化酶（SOD3）活性、丙二醛（MDA）水平与CD4细胞计数之间的关系。本研究的对象包括二十（20）名未感染HIV的志愿者作为对照组以及一百（100）名HIV感染者。四十九（49）名感染患者未接受治疗，而五十一（51）名患者处于不同治疗阶段。血清丙二醛浓度与CD4细胞计数之间存在负相关（Pearson r = -0.68，p < 0.01）。血清丙二醛浓度与细胞外超氧化物歧化酶活性之间也存在负相关（Pearson r = -0.71，p < 0.01）以及与维生素A浓度之间存在负相关（Pearson r = -0.75；p < 0.01）。相反，在HIV感染患者中观察到CD4细胞计数与细胞外超氧化物歧化酶活性之间存在正相关（Pearson r = 0.86，p < 0.01）。同样，CD4细胞计数与血清维生素A浓度之间也存在正相关（Pearson r = 0.89，p < 0.01）。在我们农村地区资源有限的医疗机构中，利用这些指标监测不适合接受治疗的HIV患者仍具有可能性。
