Süllentrop F, Hahn J, Moka D
Institute of Inorganic Chemistry and the Department of Nuclear Medicine University of Cologne, Germany.
Int J Biomed Sci. 2012 Jun;8(2):94-108.
Paraneoplastic effects are some of the major side effects of advanced renal cell carcinoma (RCC). Magnetic resonance spectroscopy (MRS) is known as a powerful tool to study cancer cell metabolism and cancer cell - host interactions. Aim of this study was to assess tumor cell metabolism and systemic effects using (1)H-MRS.
Spectroscopic analysis of 10 patients with RCC was compared with those of 15 healthy volunteers. Local tumor metabolism was assessed using image-guided (1)H-in-vivo-spectroscopy in a 1.5 Tesla MR whole body tomograph. Systemic effects of RCC were measured using (1)H-High-Resolution (HR) spectra of blood plasma samples in a 500 MHz Bruker DRX 500 spectrometer.
In-vivo-spectroscopy can significantly differentiate tumor tissue from healthy renal tissue by comparing their lipid composition. Moreover after detailed assignment of the various metabolites in blood plasma in the in-vitro-HR-spectra significant systemic alterations could be identified in patients with RCC especially regarding lipid and amino acid metabolism.
This work indicates that using (1)H-MRS both changes in tumor metabolism and resulting systemic/paraneoplastic effects can be assessed in patients with RCC. This approach therefore offers scope for diagnosis and therapy evaluation.
副肿瘤效应是晚期肾细胞癌（RCC）的一些主要副作用。磁共振波谱（MRS）是研究癌细胞代谢和癌细胞与宿主相互作用的有力工具。本研究的目的是使用氢质子磁共振波谱（1H-MRS）评估肿瘤细胞代谢和全身效应。
将10例肾细胞癌患者的光谱分析结果与15名健康志愿者的进行比较。在1.5特斯拉磁共振全身断层扫描仪中，使用图像引导的氢质子体内波谱评估局部肿瘤代谢。在500兆赫布鲁克DRX 500光谱仪中，使用血浆样本的氢质子高分辨率（HR）光谱测量肾细胞癌的全身效应。
通过比较脂质成分，体内波谱可以显著区分肿瘤组织和健康肾组织。此外，在体外高分辨率光谱中对血浆中各种代谢物进行详细鉴定后，肾细胞癌患者可发现明显的全身改变，尤其是在脂质和氨基酸代谢方面。
这项研究表明，使用氢质子磁共振波谱可以评估肾细胞癌患者的肿瘤代谢变化以及由此产生的全身/副肿瘤效应。因此，这种方法为诊断和治疗评估提供了空间。
