Departamento de Química y Biología, Universidad del Norte, Barranquilla, Atlántico, Colombia.
BMC Med Educ. 2013 May 15;13:70. doi: 10.1186/1472-6920-13-70.
We present a software tool called SENB, which allows the geometric and biophysical neuronal properties in a simple computational model of a Hodgkin-Huxley (HH) axon to be changed. The aim of this work is to develop a didactic and easy-to-use computational tool in the NEURON simulation environment, which allows graphical visualization of both the passive and active conduction parameters and the geometric characteristics of a cylindrical axon with HH properties.
The SENB software offers several advantages for teaching and learning electrophysiology. First, SENB offers ease and flexibility in determining the number of stimuli. Second, SENB allows immediate and simultaneous visualization, in the same window and time frame, of the evolution of the electrophysiological variables. Third, SENB calculates parameters such as time and space constants, stimuli frequency, cellular area and volume, sodium and potassium equilibrium potentials, and propagation velocity of the action potentials. Furthermore, it allows the user to see all this information immediately in the main window. Finally, with just one click SENB can save an image of the main window as evidence.
The SENB software is didactic and versatile, and can be used to improve and facilitate the teaching and learning of the underlying mechanisms in the electrical activity of an axon using the biophysical properties of the squid giant axon.
我们介绍了一个名为 SENB 的软件工具，它允许改变 Hodgkin-Huxley（HH）轴突简单计算模型中的几何和生物物理神经元特性。这项工作的目的是在 NEURON 模拟环境中开发一个教学和易于使用的计算工具，该工具允许对具有 HH 特性的圆柱形轴突的被动和主动传导参数以及几何特性进行图形可视化。
SENB 软件为电生理学的教学和学习提供了几个优势。首先，SENB 提供了简便和灵活的确定刺激数量的方式。其次，SENB 允许在同一窗口和时间框架内即时和同时可视化电生理学变量的演变。第三，SENB 计算了时间和空间常数、刺激频率、细胞面积和体积、钠和钾平衡电位以及动作电位的传播速度等参数。此外，它允许用户立即在主窗口中查看所有这些信息。最后，只需点击一下，SENB 就可以保存主窗口的图像作为证据。
SENB 软件具有教学和多功能性，可以用于使用鱿鱼巨大轴突的生物物理特性来改进和促进对轴突电活动的基本机制的教学和学习。
