Department of Ophthalmology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan.
Cornea. 2013 Sep;32(9):1219-23. doi: 10.1097/ICO.0b013e318294f97e.
To determine the effect of rebamipide ophthalmic suspension on optical quality in patients with dry eye with short break-up time (BUT) of the tear film.
Twenty-six eyes of 16 patients with the short BUT type of dry eye were enrolled and treated with 2% rebamipide ophthalmic suspension. At baseline and at 2 and 4 weeks after initiating the treatment, the serial corneal higher-order aberrations (HOAs), BUT, fluorescein staining, and Schirmer test were measured. Patients were asked to complete questionnaires about the changes in dry eye-related ocular symptoms after the treatment.
Before the treatment, the pattern of postblink corneal HOAs for 10 seconds showed a sawtooth pattern, with a marked upward curve that increased after blinking. Treatment with rebamipide for 4 weeks significantly (P < 0.05) improved the postblink corneal HOAs and stabilized the pattern of the corneal HOAs. Significant increases in the tear film BUT were seen 2 and 4 weeks after the treatment (P < 0.001 for both comparisons).
Rebamipide administered to treat the short BUT type of dry eye significantly improved optical quality because of the improvement in tear stability.
观察瑞巴派特对泪膜破裂时间（BUT）短的干眼患者的泪膜稳定性及眼表光学质量的影响。
选取 16 例（26 眼）BUT 短的干眼患者，给予 2%瑞巴派特眼用混悬液治疗，于治疗前、治疗后 2 周及 4 周分别观察患者的角膜高阶像差（HOAs）、BUT、荧光素染色及泪液分泌试验，评估患者的眼干相关症状，并进行问卷调查。
治疗前患者眨眼后 10 s 的角膜 HOAs 呈锯齿状改变，波阵面向上方弯曲，随眨眼逐渐恢复平坦；治疗 4 周后角膜 HOAs 明显改善，且形态趋于稳定；BUT 较治疗前明显延长（P < 0.05）。
瑞巴派特眼用混悬液可明显改善泪膜稳定性，从而提高干眼患者的眼表光学质量。
