Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Otake Clinic Moon View Eye Center, Kanagawa, Japan.
Biomed Res Int. 2022 Jan 28;2022:8159669. doi: 10.1155/2022/8159669. eCollection 2022.
The contributory factors and symptoms for presbyopia progression have not been fully determined. The purpose of the study was to compare presbyopia progression in subjects with short and normal tear breakup time and to explore the severity of common ocular symptoms associated with presbyopia progression.
We conducted a clinic-based, retrospective, cross-sectional study. Inclusion criteria were bilateral phakic patients aged 40-69 years with best-corrected distance visual acuity better than 20/30, and exclusion criteria were the use of glaucoma eye drops, any disease affecting vision, or history of ocular surgery. We measured the binocular near add power and compared the results using Kaplan-Meier analysis. Association between near add power and ocular symptoms was explored.
There were 1411 participants (mean age of 50.1 years). There were no significant differences in age, intraocular pressure, spherical equivalent, astigmatism, or anisometropia between the sexes. Kaplan-Meier analysis indicated that women with short tear breakup time reached the endpoint (near add power of +3.00 D) significantly earlier than those with normal tear breakup time ( = 0.043; Cox-Mantel test). Eye fatigue was most severe in the group with an add power of 1.25-2.00 D. Near add power was correlated with hyperopia, astigmatic errors, and anisometropia.
This study suggests an exacerbation of presbyopia progression in women with short tear breakup time. Eye fatigue was most severe in those with an add power of 1.25-2.00 D.
导致老视进展的因素和症状尚未完全确定。本研究的目的是比较泪膜破裂时间短和正常的患者的老视进展情况，并探讨与老视进展相关的常见眼部症状的严重程度。
我们进行了一项基于诊所的回顾性横断面研究。纳入标准为双眼透明、年龄 40-69 岁、最佳矫正远视力大于 20/30 的患者，排除标准为使用青光眼滴眼液、任何影响视力的疾病或眼部手术史。我们测量了双眼近附加力，并使用 Kaplan-Meier 分析比较了结果。探讨了近附加力与眼部症状之间的关系。
共有 1411 名参与者（平均年龄 50.1 岁）。性别之间在年龄、眼内压、等效球镜、散光或屈光参差方面无显著差异。Kaplan-Meier 分析表明，泪膜破裂时间短的女性达到终点（近附加力为+3.00 D）的时间明显早于泪膜破裂时间正常的女性（ = 0.043；Cox-Mantel 检验）。眼疲劳在附加力为 1.25-2.00 D 的组中最为严重。近附加力与远视、散光误差和屈光参差相关。
本研究表明，泪膜破裂时间短的女性老视进展加重。附加力为 1.25-2.00 D 的患者眼疲劳最为严重。
