Department of Neurology, University of Michigan Health System, Ann Arbor, MI 48109-5036, USA.
Semin Neurol. 2012 Nov;32(5):512-6. doi: 10.1055/s-0033-1334470. Epub 2013 May 15.
Miller Fisher's syndrome is a rare variant of Guillain-Barré's syndrome characterized by the acute development of ataxia, ophthalmoparesis, and areflexia. Most patients have a measureable antibody in serum directed against the GQ1b ganglioside. This antibody is also present in the serum of patients with other forms of Guillain-Barré's syndrome who have prominent ataxia or ophthalmoplegia as part of their clinical presentation. Miller Fisher's syndrome generally is self-limited and has an excellent prognosis.
米勒费雪综合征是吉兰-巴雷综合征的一种罕见变异型，其特征为急性共济失调、眼肌瘫痪和反射消失。大多数患者血清中存在针对 GQ1b 神经节苷脂的可测量抗体。这种抗体也存在于其他形式的吉兰-巴雷综合征患者的血清中，这些患者的临床症状突出表现为共济失调或眼肌瘫痪。米勒费雪综合征通常具有自限性，预后良好。
