Mahmoudi Mohammad Jafar, Hedayat Mona, Taghvaei Mohammad, Nematipour Ebrahim, Farhadi Elham, Esfahanian Nilufar, Sadr Maryam, Mahmoudi Maryam, Nourijelyani Keramat, Amirzargar Ali Akbar, Rezaei Nima
Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Cardiol J. 2014;21(1):24-8. doi: 10.5603/CJ.a2013.0049. Epub 2013 May 15.
As of the potential immunomodulatory effects of interleukin-4 (IL-4) and its importance in inhibiting the production of proinflammatory cytokines by monocytes and activated T cells, the IL-4 gene polymorphisms were investigated in a group of patients with chronic heart failure due to ischemic heart disease.
Forty three patients with ischemic heart failure (IHF) were enrolled in this study and compared with 139 healthy individuals. The allele and genotype frequency of 3 single nucleotide polymorphisms within the IL-4 gene were determined.
The frequency of the IL-4 -590/T allele in the patient group was significantly higher than in the control group (p < 0.0001). The most frequent genotypes in patients with IHF were IL-4 (-590) CC (p < 0.0001), IL-4 (-33) CC (p = 0.021), and IL-4 (-33) TT (p < 0.0001). The frequency of the following genotypes was significantly lower in patients compared to controls: IL-4 (-1098) TG (p = 0.035), IL-4 (-590) TC (p < 0.0001), and IL-4 (-33) TC (p < 0.0001). The most frequent IL-4 haplotypes in the patient group, which were significantly higher than in the control group, were TCC (p < 0.0001), TCT (p = 0.0242), and GCT (p = 0.0108) haplotypes. In contrast, the frequencies of the following haplotypes in the patient group were significantly lower than in the controls: GCC (p = 0.032), TTT (p = 0.0268), and TTC (p = 0.0399).
Certain alleles, genotypes, and haplotypes in IL-4 gene were over represented inpatients with IHF, which may, in turn, predispose individuals to this disease.
鉴于白细胞介素-4（IL-4）潜在的免疫调节作用及其在抑制单核细胞和活化T细胞产生促炎细胞因子方面的重要性，对一组缺血性心脏病所致慢性心力衰竭患者的IL-4基因多态性进行了研究。
本研究纳入了43例缺血性心力衰竭（IHF）患者，并与139名健康个体进行比较。测定了IL-4基因内3个单核苷酸多态性的等位基因和基因型频率。
患者组中IL-4 -590/T等位基因频率显著高于对照组（p < 0.0001）。IHF患者中最常见的基因型为IL-4（-590）CC（p < 0.0001）、IL-4（-33）CC（p = 0.021）和IL-4（-33）TT（p < 0.0001）。与对照组相比，患者中以下基因型的频率显著较低：IL-4（-1098）TG（p = 0.035）、IL-4（-590）TC（p < 0.0001）和IL-4（-33）TC（p < 0.0001）。患者组中最常见的IL-4单倍型，显著高于对照组的，为TCC（p < 0.0001）、TCT（p = 0.0242）和GCT（p = 0.0108）单倍型。相反，患者组中以下单倍型的频率显著低于对照组：GCC（p = 0.032）、TTT（p = 0.0268）和TTC（p = 0.0399）。
IL-4基因中的某些等位基因、基因型和单倍型在IHF患者中过度表达，这可能反过来使个体易患该病。
