Kassem Kamal M, Ali Mahboob, Rhaleb Nour-Eddine
Department of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, OH, USA.
Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
J Cardiovasc Pharmacol Ther. 2020 Jan;25(1):7-14. doi: 10.1177/1074248419868699. Epub 2019 Aug 11.
Hypertension is one of the major physiological risk factors for cardiovascular diseases, and it affects more than 1 billion adults worldwide, killing 9 million people every year according to World Health Organization. Also, hypertension is associated with increased risk of kidney disease and stroke. Studying the risk factors that contribute to the pathogenesis of hypertension is key to preventing and controlling hypertension. Numerous laboratories around to globe are very active pursuing research studies to delineate the factors, such as the role of immune system, which could contribute to hypertension. There are studies that were conducted on immune-deficient mice for which experimentally induced hypertension has been ameliorated. Thus, there are possibilities that immune reactivity could be associated with the development of certain type of hypertension. Furthermore, interleukin 4 has been associated with the development of pulmonary hypertension, which could lead to right ventricular remodeling. Also, the immune system is involved in valvular and nonvalvular cardiac remodeling. It has been demonstrated that there is a causative relationship between different interleukins and cardiac fibrosis.
高血压是心血管疾病的主要生理风险因素之一，全球有超过10亿成年人受其影响，据世界卫生组织统计，每年有900万人死于高血压。此外，高血压还与肾病和中风风险增加有关。研究导致高血压发病的风险因素是预防和控制高血压的关键。全球众多实验室都在积极开展研究，以确定可能导致高血压的因素，比如免疫系统的作用。有研究对免疫缺陷小鼠进行实验，结果显示实验性诱导的高血压得到了改善。因此，免疫反应性有可能与某些类型高血压的发生有关。此外，白细胞介素4与肺动脉高压的发生有关，而肺动脉高压可能导致右心室重塑。而且，免疫系统还参与瓣膜性和非瓣膜性心脏重塑。已经证明，不同白细胞介素与心脏纤维化之间存在因果关系。
