Güler Gamze Babur, Batgerel Ulaankhuu, Güler Ekrem, Karaca Oğuz, Geçmen Cetin, Güneş Hacı Murat, Aguş Hicaz Zencirkıran, Esen Ali Metin, Türkmen Mehmet Muhsin
Istinye State Hospital, Istanbul, Turkey.
Cardiol J. 2014;21(1):6-10. doi: 10.5603/CJ.a2013.0046. Epub 2013 May 15.
The aim of the study was to examine the frequency of factor XIII polymorphism among patients with cardiac syndrome X (CSX).
This study was designed as a cross-sectional and observational study. Forty-eight female patients with CSX and 36 controls matched by age, gender, diabetes, and hypertension were studied. CSX was defined as typical chest pain during rest or effort, abnormal test result for exercise ECG, and presence of angiographically normal epicardial coronary arteries after ruling out inducible spasm. Factor XIII gene polymorphism was investigated by using CVD Strip Assay (ViennaLab Diagnostic GmbH) commercial kit.
The frequency of factor XIII (Val/Leu + Leu/Leu) mutation was significantly higher in patients with CSX (43%) than in controls (19%) (p = 0.02). Frequency of the Leu allele was significantly higher in the patient group (23.5% vs. 11.1%, p = 0.04). Factor XIII (Val/Leu + Leu/Leu) mutation (p = 0.01, OR = 3.42; 95% CI 1.22-9.58) and smoking (p = 0.04, OR = 3.33, 95% CI 1.05-10.58) were identified as independent predictors of the disease in multivariate regression analysis.
This study indicates that there is an evidence for association between factor XIII Val34Leu polymorphism and CSX.
本研究旨在调查心脏综合征X（CSX）患者中凝血因子XIII多态性的频率。
本研究设计为横断面观察性研究。对48例CSX女性患者和36例年龄、性别、糖尿病及高血压相匹配的对照者进行研究。CSX定义为休息或运动时典型胸痛、运动心电图检查结果异常，且排除诱发痉挛后冠状动脉造影显示心外膜冠状动脉正常。采用CVD Strip Assay（ViennaLab Diagnostic GmbH）商业试剂盒检测凝血因子XIII基因多态性。
CSX患者中凝血因子XIII（Val/Leu + Leu/Leu）突变的频率（43%）显著高于对照组（19%）（p = 0.02）。患者组中Leu等位基因频率显著更高（23.5%对11.1%，p = 0.04）。在多因素回归分析中，凝血因子XIII（Val/Leu + Leu/Leu）突变（p = 0.01，OR = 3.42；95%CI 1.22 - 9.58）和吸烟（p = 0.04，OR = 3.33，95%CI 1.05 - 10.58）被确定为该疾病的独立预测因素。
本研究表明有证据支持凝血因子XIII Val34Leu多态性与CSX之间存在关联。
