Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Bioimpacts. 2011;1(1):7-22. doi: 10.5681/bi.2011.003. Epub 2011 Jun 9.
The integrity of the cells/tissues in anterior and/or posterior segments of the eye plays a crucial role in biofunctions of the vision. To maintain ocular homeostasis, selective restrictiveness of the ophthalmic membranes and barriers control must act on shuttling of biomolecules. Thus, not all attempts to apply de novo nanotechnology approaches for ocular pharmacotherapy have met with the same successes as those cited here in this review, and sometimes these novel technologies tools provoke a great deal of challenges and hurdles mainly because of functional presence of these barriers.
Recent published articles related to applications of ocular nanomedicines were reviewed and highlighted in this review article.
It seems the emergence of nanomedicines have arisen great hopes for ophthalmic pharmacotherapy, in which nanostructured medicines are expected to be able to cross the restrictive barriers of the eye. Although such fast inauguration of ocular nanomedicines will literally convey new challenges in the regulatory and translational processes, it will also grant a prolific platform from which many exciting, and yet unimagined, applications of biomedical nanotechnology will emerge for pharmacotherapy of the eye.
This review provides recent advancements on ocular nanomedicines.
眼球前段和/或后段细胞/组织的完整性对视觉生物功能起着至关重要的作用。为了维持眼内环境稳定，眼内膜和屏障选择性限制必须对生物分子的转运起作用。因此，并非所有应用眼科药物治疗的新纳米技术方法都像本文所引用的那样取得了相同的成功，有时这些新技术工具会带来许多挑战和障碍，主要是因为这些屏障的功能存在。
本文综述了与眼部纳米医学应用相关的近期已发表文章。
纳米医学的出现似乎给眼科药物治疗带来了巨大的希望，人们期望纳米药物能够穿透眼睛的限制屏障。尽管这种眼科纳米医学的快速出现将在监管和转化过程中带来新的挑战，但它也将提供一个多产的平台，许多令人兴奋的、尚未想象到的生物医学纳米技术应用将涌现出来，用于眼部药物治疗。
本文综述了眼部纳米医学的最新进展。
