University of Salento, Department of Mathematics and Physics "Ennio De Giorgi", Via Arnesano, 73100 Lecce, Italy.
University College London, Department of Chemistry, 20 Gordon Street, London WC1H 0AJ, UK.
Cells. 2020 Mar 10;9(3):679. doi: 10.3390/cells9030679.
We are witnessing an exponential increase in the use of different nanomaterials in a plethora of biomedical fields. We are all aware of how nanoparticles (NPs) have influenced and revolutionized the way we supply drugs or how to use them as therapeutic agents thanks to their tunable physico-chemical properties. However, there is still a niche of applications where NP have not yet been widely explored. This is the field of ocular delivery and NP-based therapy, which characterizes the topic of the current review. In particular, many efforts are being made to develop nanosystems capable of reaching deeper sections of the eye such as the retina. Particular attention will be given here to noble metal (gold and silver), and to polymeric nanoparticles, systems consisting of lipid bilayers such as liposomes or vesicles based on nonionic surfactant. We will report here the most relevant literature on the use of different types of NPs for an efficient delivery of drugs and bio-macromolecules to the eyes or as active therapeutic tools.
我们正在见证不同纳米材料在众多生物医学领域中的应用呈指数级增长。我们都知道，由于纳米颗粒（NPs）具有可调节的物理化学性质，它们已经影响和改变了我们供应药物或将其用作治疗剂的方式。然而，仍然有一些应用领域尚未广泛探索 NP 的应用。这就是眼部给药和基于 NP 的治疗领域，这是当前综述的主题。特别是，人们正在努力开发能够到达眼睛更深部位的纳米系统，如视网膜。这里将特别关注贵金属（金和银）和聚合物纳米颗粒、由脂质双层组成的系统，例如基于非离子表面活性剂的脂质体或囊泡。我们将在这里报告关于使用不同类型的 NPs 将药物和生物大分子有效递送到眼睛或作为有效治疗工具的最相关文献。
