甲状旁腺激素作为慢性阻塞性肺疾病的新型生物标志物：韩国国家健康与营养检查调查
Parathyroid Hormone as a Novel Biomarker for Chronic Obstructive Pulmonary Disease: Korean National Health and Nutrition Examination Survey.
作者信息
Park Joo-Hyun, Park Hye Kyeong, Jung Hoon, Lee Sung-Soon, Koo Hyeon-Kyoung
机构信息
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ilsan Paik Hospital, Inje University college of Medicine, Goyang, Korea.
出版信息
PLoS One. 2015 Sep 23;10(9):e0138482. doi: 10.1371/journal.pone.0138482. eCollection 2015.
OBJECTIVE
To understand and predict chronic obstructive pulmonary disease (COPD), a biomarker that reflects disease severity is needed.
RESEARCH DESIGN AND METHODS
Data from 10269 adults aged over 40 years of age were retrieved from the Korea National Health and Nutrition Examination Survey (KNHANES), and 1302 patients met the criteria for COPD. The association between values of vitamin D and parathyroid hormone (PTH), and COPD severity including lung function and quality of life, were analyzed.
RESULTS
In COPD patients, lung function was inversely related to PTH values (P = 0.02 for FVC [% predicted]; P < 0.001 for FEV1 [% predicted]); however, the association of lung function with vitamin D levels was not statistically significant in a multivariable analysis. Value of PTH was independently associated with EQ5D-index (P = 0.04), but vitamin D level showed no significant relationship with EQ5D-index (P = 0.59) or EQ5D-VAS (P = 0.81).
CONCLUSIONS
Elevation of PTH, unlike vitamin D, is independently associated with COPD severity, and may be a better biomarker for COPD.
目的
为了解和预测慢性阻塞性肺疾病（COPD），需要一种能够反映疾病严重程度的生物标志物。
研究设计与方法
从韩国国家健康与营养检查调查（KNHANES）中检索了10269名40岁以上成年人的数据，其中1302名患者符合COPD标准。分析了维生素D和甲状旁腺激素（PTH）值与包括肺功能和生活质量在内的COPD严重程度之间的关联。
结果
在COPD患者中，肺功能与PTH值呈负相关（FVC[预测值%]，P = 0.02；FEV1[预测值%]，P < 0.001）；然而，在多变量分析中，肺功能与维生素D水平的关联无统计学意义。PTH值与EQ5D指数独立相关（P = 0.04），但维生素D水平与EQ5D指数（P = 0.59）或EQ5D视觉模拟量表（VAS）（P = 0.81）无显著关系。
结论
与维生素D不同，PTH升高与COPD严重程度独立相关，可能是COPD更好的生物标志物。
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