Tian Xin, Tian Ye, Ma Ping, Sui Cheng-Guang, Meng Fan-Dong, Li Yan, Fu Li-Ye, Jiang Tao, Wang Yang, Ji Fu-Jian, Fang Xue-Dong, Jiang You-Hong
Molecular Oncology Department of Cancer Research Institute, the First Affiliated Hospital, China Medical University, Shenyang, China.
Asian Pac J Cancer Prev. 2013;14(3):1925-9. doi: 10.7314/apjcp.2013.14.3.1925.
As a negative regulator of P53, MDM2 plays an important role in carcinogenesis; a polymorphism in its promoter region. SNP309 T>G, is known to increase the expression of MDM2, thus being considered related to higher susceptibility to neoplasia. However, no agreement has been achieved regarding its effects on gastric cancer.
The present systematic meta-analysis was performed based on comprehensive literature search from Pubmed, Web of science and CBM databases.
It was suggested from 6 independent studies that the GG genotype is associated with a significantly increased risk of gastric cancer (Recessive: OR = 1.43, 95% CI = 1.08-1.91, P = 0.013), and subgroup analysis also confirmed the relationship (English publications-recessive model: OR = 1.45, 95% CI = 1.10-1.91, P = 0.009; Studies in China-recessive model: OR = 1.58, 95% CI = 1.08-2.30, P = 0.017). No publication bias was detected.
The meta-analysis indicated a significant inverse association between GG genotype carriage and elevated risk of gastric cancer. However, more studies and detailed information are needed to fully address the topic.
作为P53的负调节因子，MDM2在肿瘤发生过程中发挥重要作用；其启动子区域存在单核苷酸多态性，即SNP309 T>G，已知该多态性会增加MDM2的表达，因此被认为与肿瘤易感性增加有关。然而，关于其对胃癌的影响尚未达成共识。
本系统荟萃分析基于对来自PubMed、科学网和中国生物医学文献数据库的文献进行全面检索而开展。
6项独立研究表明，GG基因型与胃癌风险显著增加相关（隐性模型：OR = 1.43，95% CI = 1.08 - 1.91，P = 0.013），亚组分析也证实了这种关系（英文出版物 - 隐性模型：OR = 1.45，95% CI = 1.10 - 1.91，P = 0.009；中国研究 - 隐性模型：OR = 1.58，95% CI = 1.08 - 2.30，P = 0.017）。未检测到发表偏倚。
荟萃分析表明GG基因型携带与胃癌风险升高之间存在显著的负相关。然而，需要更多研究和详细信息来全面探讨该主题。
