Carter D C, Forrest J A, Werner M, Heading R C, Park J, Shearman D J
Br Med J. 1974 Aug 31;3(5930):554-6. doi: 10.1136/bmj.3.5930.554.
Metiamide, an antagonist of histamine H(2) receptors, was administered intravenously to normal subjects and to patients with a peptic ulcer during vagal stimulation with a constant infusion of insulin. In normal and peptic-ulcer subjects there were reductions of 70% and 71% respectively in gastric-acid output compared with control tests on the same subjects. The decreased acid output resulted from a reduction in both volume of secretion and acid concentration. Metiamide is therefore a potent inhibitor of vagally-induced gastric acid secretion.
甲硫米特，一种组胺H₂受体拮抗剂，在持续输注胰岛素进行迷走神经刺激期间，被静脉注射给正常受试者和消化性溃疡患者。与对相同受试者进行的对照试验相比，正常受试者和消化性溃疡受试者的胃酸分泌量分别减少了70%和71%。胃酸分泌量的减少是由于分泌量和酸浓度均降低所致。因此，甲硫米特是迷走神经诱导的胃酸分泌的有效抑制剂。
