Department of Pharmacology and Center for Compulsive Behaviors and Addiction, Rush University, Chicago, IL, United States.
Neurosci Biobehav Rev. 2013 Nov;37(9 Pt A):2081-6. doi: 10.1016/j.neubiorev.2013.05.002. Epub 2013 May 13.
Stimuli, including contexts, which predict the availability or onset of a drug effect, can acquire conditioned incentive motivational properties. These conditioned properties endure after withdrawal, and can promote drug-seeking which may result in relapse. Conditioned place preference (CPP) assesses the associations between drugs and the context in which they are experienced. Here, we review the potential utility of CPP procedures in rodents and humans to evaluate medications that target conditioned drug-seeking responses. We discuss the translational potential of the CPP procedure from rodents to humans, and review findings with FDA-approved treatments that support the use of CPP to develop relapse-reduction medications. We also discuss challenges and methodological questions in applying the CPP procedure to this purpose. We argue that an efficient and valid CPP procedure in humans may reduce the burden of full clinical trials with drug-abusing patients that are currently required for testing promising treatments.
刺激物，包括预测药物效应出现或可得性的环境，能够获得条件性激励动机属性。这些条件属性在戒断后仍能持续存在，并能促进药物寻求，可能导致复吸。条件性位置偏爱（CPP）评估药物与体验药物的环境之间的关联。在这里，我们回顾了 CPP 程序在啮齿动物和人类中的潜在效用，以评估针对条件性觅药反应的药物。我们讨论了 CPP 程序从啮齿动物到人类的转化潜力，并回顾了 FDA 批准的治疗方法的发现，这些方法支持使用 CPP 开发减少复吸的药物。我们还讨论了将 CPP 程序应用于该目的所面临的挑战和方法学问题。我们认为，在人类中建立一种高效和有效的 CPP 程序，可能会减少目前对有前途的治疗方法进行测试所需的、对滥用药物患者进行完整临床试验的负担。
