Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, MS BCM620, Houston, TX 77030.
J Gerontol A Biol Sci Med Sci. 2014 Feb;69(2):152-9. doi: 10.1093/gerona/glt055. Epub 2013 May 16.
To investigate the effect of growth hormone and insulin-like growth factor 1 deficiency on the aging mouse arterial system, we compared the hemodynamics in young (4 months) and old (30 months) growth hormone-releasing hormone receptor null dwarf (Little) mice and their wild-type littermates. Young Little mice had significantly lower peak and mean aortic velocity and significantly higher aortic impedance than young wild-type mice. However, unlike the wild-type mice, there were no significant changes in arterial function with age in the Little mice. Aortic pulse wave velocity estimated using characteristic impedance increased with age in the wild-type mice, but it changed minimally in the Little mouse. We therefore conclude that arterial function in Little mice expresses a premature aging phenotype at young age and may neither enhance nor reduce their longevity.
为了研究生长激素和胰岛素样生长因子 1 缺乏对衰老小鼠动脉系统的影响，我们比较了年轻（4 个月）和年老（30 个月）生长激素释放激素受体缺失（Little）小鼠及其野生型同窝仔鼠的血液动力学。年轻的 Little 小鼠的峰值和平均主动脉速度明显较低，主动脉阻抗明显较高。然而，与野生型小鼠不同的是，Little 小鼠的动脉功能随年龄的增长没有明显变化。使用特征阻抗估计的主动脉脉搏波速度在野生型小鼠中随年龄增长而增加，但在 Little 小鼠中变化很小。因此，我们得出结论，年轻的 Little 小鼠的动脉功能表现出一种早衰表型，既不会延长也不会缩短它们的寿命。
