Institut Pasteur, Département d'Immunologie, Centre d'Immunologie Humaine, Paris, France.
Curr Opin Immunol. 2013 Jun;25(3):313-20. doi: 10.1016/j.coi.2013.04.001. Epub 2013 May 15.
Recent progress has begun to reveal the often complex and changing roles of phosphotyrosine and phosphoinositide phosphatases in regulation of immunoreceptor signaling. The resultant confusion has been further increased by discoveries of new players. Here we provide a review of recent progress in defining the roles of these enzymes in immunoreceptor-dependent mast cell, T cell and B cell activation.
近年来的研究进展开始揭示磷酸酪氨酸和磷酸肌醇酯磷酸酶在免疫受体信号转导调控中所扮演的角色通常是复杂且多变的。新发现的参与者进一步增加了这种混乱。本文综述了近年来在鉴定这些酶在免疫受体依赖性肥大细胞、T 细胞和 B 细胞激活中作用的研究进展。
