双侧颈总动脉闭塞作为一种适当的预处理刺激，可诱导对局灶性脑缺血的早期缺血耐受。
Bilateral common carotid artery occlusion as an adequate preconditioning stimulus to induce early ischemic tolerance to focal cerebral ischemia.
作者信息
Speetzen Lukas Julius, Endres Matthias, Kunz Alexander
机构信息
Department of Neurology, Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Germany.
出版信息
J Vis Exp. 2013 May 9(75):e4387. doi: 10.3791/4387.
Abstract
There is accumulating evidence, that ischemic preconditioning - a non-damaging ischemic challenge to the brain - confers a transient protection to a subsequent damaging ischemic insult. We have established bilateral common carotid artery occlusion as a preconditioning stimulus to induce early ischemic tolerance to transient focal cerebral ischemia in C57Bl6/J mice. In this video, we will demonstrate the methodology used for this study.
摘要
越来越多的证据表明，缺血预处理——一种对大脑无害的缺血刺激——能对随后的损伤性缺血性损伤产生短暂的保护作用。我们已经建立了双侧颈总动脉闭塞作为预处理刺激，以诱导C57Bl6/J小鼠对短暂局灶性脑缺血产生早期缺血耐受性。在本视频中，我们将展示该研究使用的方法。
相似文献
1
Bilateral common carotid artery occlusion as an adequate preconditioning stimulus to induce early ischemic tolerance to focal cerebral ischemia.双侧颈总动脉闭塞作为一种适当的预处理刺激，可诱导对局灶性脑缺血的早期缺血耐受。
J Vis Exp. 2013 May 9(75):e4387. doi: 10.3791/4387.
2
A forebrain ischemic preconditioning model established in C57Black/Crj6 mice.在C57Black/Crj6小鼠中建立的前脑缺血预处理模型。
J Neurosci Methods. 2001 May 30;107(1-2):101-6. doi: 10.1016/s0165-0270(01)00356-9.
3
4
Noninvasive limb remote ischemic preconditioning contributes neuroprotective effects via activation of adenosine A1 receptor and redox status after transient focal cerebral ischemia in rats.非侵入性肢体远程缺血预处理通过激活大鼠短暂性局灶性脑缺血后的腺苷 A1 受体和氧化还原状态发挥神经保护作用。
Brain Res. 2012 Jun 12;1459:81-90. doi: 10.1016/j.brainres.2012.04.017. Epub 2012 Apr 17.
5
Improved regional cerebral blood flow is important for the protection seen in a mouse model of late phase ischemic preconditioning.改善局部脑血流对于在晚期缺血预处理小鼠模型中所观察到的保护作用很重要。
Brain Res. 2006 Nov 22;1121(1):231-7. doi: 10.1016/j.brainres.2006.08.107. Epub 2006 Sep 29.
6
Focal ischemic preconditioning induces rapid tolerance to middle cerebral artery occlusion in mice.局灶性缺血预处理可诱导小鼠对大脑中动脉闭塞产生快速耐受性。
J Cereb Blood Flow Metab. 1999 Jul;19(7):757-61. doi: 10.1097/00004647-199907000-00005.
7
[The prior occlusion of bilateral vertebral arteries during producing global cerebral ischemic damage model may play a protective role as preconditioning].在制作全脑缺血损伤模型过程中预先阻断双侧椎动脉可能作为预处理发挥保护作用。
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2007 Feb;23(1):24-9.
8
Prevention of inflammation is a mechanism of preconditioning-induced neuroprotection against focal cerebral ischemia.预防炎症是预处理诱导的针对局灶性脑缺血的神经保护机制。
Neurochem Int. 2006 Jul;49(2):127-35. doi: 10.1016/j.neuint.2006.02.011. Epub 2006 Jun 6.
9
Neurogenic pathway mediated remote preconditioning protects the brain from transient focal ischemic injury.神经通路介导的远程预处理可保护大脑免受短暂性局灶性缺血损伤。
Brain Res. 2011 Apr 22;1386:184-90. doi: 10.1016/j.brainres.2011.02.032. Epub 2011 Feb 19.
10
Delayed tolerance with repetitive transient focal ischemic preconditioning in the mouse.小鼠重复性短暂局灶性缺血预处理诱导的延迟性耐受
Stroke. 2008 Mar;39(3):967-74. doi: 10.1161/STROKEAHA.107.497412. Epub 2008 Jan 31.
引用本文的文献
1
Naringenin Attenuates Cognitive Impairment in a Rat Model of Vascular Dementia by Inhibiting Hippocampal Oxidative Stress and Inflammatory Response and Promoting N-Methyl-D-Aspartate Receptor Signaling Pathway.柚皮素通过抑制海马氧化应激和炎症反应以及促进N-甲基-D-天冬氨酸受体信号通路减轻血管性痴呆大鼠模型的认知障碍。
Neurochem Res. 2022 Nov;47(11):3402-3413. doi: 10.1007/s11064-022-03696-9. Epub 2022 Aug 26.
2
Hydrogen-Rich Water Improves Cognitive Ability and Induces Antioxidative, Antiapoptotic, and Anti-Inflammatory Effects in an Acute Ischemia-Reperfusion Injury Mouse Model.富氢水可改善认知能力，并在急性缺血再灌注损伤小鼠模型中诱导抗氧化、抗凋亡和抗炎作用。
Biomed Res Int. 2021 Oct 27;2021:9956938. doi: 10.1155/2021/9956938. eCollection 2021.
3
Ameliorative Effect of Parishin C Against Cerebral Ischemia-Induced Brain Tissue Injury by Reducing Oxidative Stress and Inflammatory Responses in Rat Model.帕里辛C通过减轻大鼠模型的氧化应激和炎症反应对脑缺血诱导的脑组织损伤的改善作用
Neuropsychiatr Dis Treat. 2021 Jun 4;17:1811-1823. doi: 10.2147/NDT.S309065. eCollection 2021.
4
Bilateral Carotid Artery Occlusion and Cochlear Oxidative Stress and Hearing Loss in Rats.大鼠双侧颈动脉闭塞与耳蜗氧化应激及听力损失
Basic Clin Neurosci. 2020 Nov-Dec;11(6):821-829. doi: 10.32598/bcn.11.6.1154.1. Epub 2020 Nov 1.
5
Granulocyte-colony stimulating factor gene therapy as a novel therapeutics for stroke in a mouse model.粒细胞集落刺激因子基因治疗作为一种新型疗法在小鼠模型中治疗中风。
J Biomed Sci. 2020 Oct 30;27(1):99. doi: 10.1186/s12929-020-00692-5.
6
Efficacy of adipose derived stem cells on functional and neurological improvement following ischemic stroke: a systematic review and meta-analysis.脂肪来源干细胞对缺血性脑卒中后功能和神经功能改善的疗效：系统评价和荟萃分析。
BMC Neurol. 2020 Aug 10;20(1):294. doi: 10.1186/s12883-020-01865-3.
7
Role of HMGB1 in an Animal Model of Vascular Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion.HMGB1 在慢性脑低灌注诱导血管性认知障碍动物模型中的作用。
Int J Mol Sci. 2020 Mar 21;21(6):2176. doi: 10.3390/ijms21062176.
8
Oxiracetam ameliorates cognitive deficits in vascular dementia rats by regulating the expression of neuronal apoptosis/autophagy-related genes associated with the activation of the Akt/mTOR signaling pathway.牛磺酸通过调节与 Akt/mTOR 信号通路激活相关的神经元凋亡/自噬相关基因的表达改善血管性痴呆大鼠的认知功能障碍。
Braz J Med Biol Res. 2019 Nov 7;52(11):e8371. doi: 10.1590/1414-431X20198371. eCollection 2019.
9
Neuroprotective potential of exercise preconditioning in stroke.运动预处理在中风中的神经保护潜力。
Cond Med. 2017;1(1):27-34.
10
Caffeine Modulates Spontaneous Adenosine and Oxygen Changes during Ischemia and Reperfusion.咖啡因调节缺血再灌注期间的自发腺苷和氧变化。
ACS Chem Neurosci. 2019 Apr 17;10(4):1941-1949. doi: 10.1021/acschemneuro.8b00251. Epub 2018 Oct 9.
本文引用的文献
1
Modeling stroke in mice - middle cerebral artery occlusion with the filament model.小鼠中风建模——丝线模型大脑中动脉闭塞法
J Vis Exp. 2011 Jan 6(47):2423. doi: 10.3791/2423.
2
Heart disease and stroke statistics--2011 update: a report from the American Heart Association.心脏病和中风统计数据--2011 年更新：来自美国心脏协会的报告。
Circulation. 2011 Feb 1;123(4):e18-e209. doi: 10.1161/CIR.0b013e3182009701. Epub 2010 Dec 15.
3
RODENT STROKE MODEL GUIDELINES FOR PRECLINICAL STROKE TRIALS (1ST EDITION).临床前卒中试验啮齿动物卒中模型指南（第1版）
J Exp Stroke Transl Med. 2009 Jan 1;2(2):2-27. doi: 10.6030/1939-067x-2.2.2.
4
Isoflurane preconditioning improves short-term and long-term neurological outcome after focal brain ischemia in adult rats.异氟烷预处理可改善成年大鼠局灶性脑缺血后的短期和长期神经功能预后。
Neuroscience. 2009 Dec 1;164(2):497-506. doi: 10.1016/j.neuroscience.2009.08.011. Epub 2009 Aug 11.
5
Future demographic trends decrease the proportion of ischemic stroke patients receiving thrombolytic therapy: a call to set-up therapeutic studies in the very old.未来人口趋势降低了接受溶栓治疗的缺血性中风患者比例：呼吁开展针对高龄患者的治疗研究。
Stroke. 2009 May;40(5):1900-2. doi: 10.1161/STROKEAHA.108.531061. Epub 2009 Feb 26.
6
Neurovascular protection by ischemic tolerance: role of nitric oxide and reactive oxygen species.缺血耐受的神经血管保护作用：一氧化氮和活性氧的作用。
J Neurosci. 2007 Jul 4;27(27):7083-93. doi: 10.1523/JNEUROSCI.1645-07.2007.
7
iNOS-derived NO and nox2-derived superoxide confer tolerance to excitotoxic brain injury through peroxynitrite.诱导型一氧化氮合酶衍生的一氧化氮和NADPH氧化酶2衍生的超氧化物通过过氧亚硝酸盐赋予对兴奋性毒性脑损伤的耐受性。
J Cereb Blood Flow Metab. 2007 Aug;27(8):1453-62. doi: 10.1038/sj.jcbfm.9600449. Epub 2007 Feb 7.
8
Established treatments for acute ischaemic stroke.急性缺血性中风的既定治疗方法。
Lancet. 2007 Jan 27;369(9558):319-30. doi: 10.1016/S0140-6736(07)60154-8.
9
Cerebral preconditioning and ischaemic tolerance.脑预处理与缺血耐受性
Nat Rev Neurosci. 2006 Jun;7(6):437-48. doi: 10.1038/nrn1927.
10
Modification of the method of thread manufacture improves stroke induction rate and reduces mortality after thread-occlusion of the middle cerebral artery in young or aged rats.丝线制作方法的改进提高了年轻或老年大鼠大脑中动脉丝线闭塞后的卒中诱导率并降低了死亡率。
J Neurosci Methods. 2006 Sep 15;155(2):285-90. doi: 10.1016/j.jneumeth.2006.01.020. Epub 2006 Feb 28.
Zotero 插件