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本文引用的文献

1
Modeling stroke in mice - middle cerebral artery occlusion with the filament model.小鼠中风建模——丝线模型大脑中动脉闭塞法
J Vis Exp. 2011 Jan 6(47):2423. doi: 10.3791/2423.
2
Heart disease and stroke statistics--2011 update: a report from the American Heart Association.心脏病和中风统计数据--2011 年更新：来自美国心脏协会的报告。
Circulation. 2011 Feb 1;123(4):e18-e209. doi: 10.1161/CIR.0b013e3182009701. Epub 2010 Dec 15.
3
RODENT STROKE MODEL GUIDELINES FOR PRECLINICAL STROKE TRIALS (1ST EDITION).临床前卒中试验啮齿动物卒中模型指南（第1版）
J Exp Stroke Transl Med. 2009 Jan 1;2(2):2-27. doi: 10.6030/1939-067x-2.2.2.
4
Isoflurane preconditioning improves short-term and long-term neurological outcome after focal brain ischemia in adult rats.异氟烷预处理可改善成年大鼠局灶性脑缺血后的短期和长期神经功能预后。
Neuroscience. 2009 Dec 1;164(2):497-506. doi: 10.1016/j.neuroscience.2009.08.011. Epub 2009 Aug 11.
5
Future demographic trends decrease the proportion of ischemic stroke patients receiving thrombolytic therapy: a call to set-up therapeutic studies in the very old.未来人口趋势降低了接受溶栓治疗的缺血性中风患者比例：呼吁开展针对高龄患者的治疗研究。
Stroke. 2009 May;40(5):1900-2. doi: 10.1161/STROKEAHA.108.531061. Epub 2009 Feb 26.
6
Neurovascular protection by ischemic tolerance: role of nitric oxide and reactive oxygen species.缺血耐受的神经血管保护作用：一氧化氮和活性氧的作用。
J Neurosci. 2007 Jul 4;27(27):7083-93. doi: 10.1523/JNEUROSCI.1645-07.2007.
7
iNOS-derived NO and nox2-derived superoxide confer tolerance to excitotoxic brain injury through peroxynitrite.诱导型一氧化氮合酶衍生的一氧化氮和NADPH氧化酶2衍生的超氧化物通过过氧亚硝酸盐赋予对兴奋性毒性脑损伤的耐受性。
J Cereb Blood Flow Metab. 2007 Aug;27(8):1453-62. doi: 10.1038/sj.jcbfm.9600449. Epub 2007 Feb 7.
8
Established treatments for acute ischaemic stroke.急性缺血性中风的既定治疗方法。
Lancet. 2007 Jan 27;369(9558):319-30. doi: 10.1016/S0140-6736(07)60154-8.
9
Cerebral preconditioning and ischaemic tolerance.脑预处理与缺血耐受性
Nat Rev Neurosci. 2006 Jun;7(6):437-48. doi: 10.1038/nrn1927.
10
Modification of the method of thread manufacture improves stroke induction rate and reduces mortality after thread-occlusion of the middle cerebral artery in young or aged rats.丝线制作方法的改进提高了年轻或老年大鼠大脑中动脉丝线闭塞后的卒中诱导率并降低了死亡率。
J Neurosci Methods. 2006 Sep 15;155(2):285-90. doi: 10.1016/j.jneumeth.2006.01.020. Epub 2006 Feb 28.

双侧颈总动脉闭塞作为一种适当的预处理刺激，可诱导对局灶性脑缺血的早期缺血耐受。

Bilateral common carotid artery occlusion as an adequate preconditioning stimulus to induce early ischemic tolerance to focal cerebral ischemia.

作者信息

Speetzen Lukas Julius, Endres Matthias, Kunz Alexander

机构信息

Department of Neurology, Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Germany.

出版信息

J Vis Exp. 2013 May 9(75):e4387. doi: 10.3791/4387.

DOI:10.3791/4387
PMID:23685461
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3679616/
Abstract

There is accumulating evidence, that ischemic preconditioning - a non-damaging ischemic challenge to the brain - confers a transient protection to a subsequent damaging ischemic insult. We have established bilateral common carotid artery occlusion as a preconditioning stimulus to induce early ischemic tolerance to transient focal cerebral ischemia in C57Bl6/J mice. In this video, we will demonstrate the methodology used for this study.

摘要

越来越多的证据表明，缺血预处理——一种对大脑无害的缺血刺激——能对随后的损伤性缺血性损伤产生短暂的保护作用。我们已经建立了双侧颈总动脉闭塞作为预处理刺激，以诱导C57Bl6/J小鼠对短暂局灶性脑缺血产生早期缺血耐受性。在本视频中，我们将展示该研究使用的方法。