人乳头瘤病毒感染：疣或癌症？
Human papillomavirus infections: warts or cancer?
机构信息
Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294-0005, USA.
出版信息
Cold Spring Harb Perspect Biol. 2013 Jul 1;5(7):a012997. doi: 10.1101/cshperspect.a012997.
Abstract
Human papillomaviruses (HPVs) are prevalent pathogens of mucosal and cutaneous epithelia. Productive infections of squamous epithelia lead to benign hyperproliferative warts, condylomata, or papillomas. Persistent infections of the anogenital mucosa by high-risk HPV genotypes 16 and 18 and closely related types can infrequently progress to high-grade intraepithelial neoplasias, carcinomas-in-situ, and invasive cancers in women and men. HPV-16 is also associated with a fraction of head and neck cancers. We discuss the interactions of the mucosotropic HPVs with the host regulatory proteins and pathways that lead to benign coexistence and enable HPV DNA amplification or, alternatively, to cancers that no longer support viral production.
摘要
人乳头瘤病毒（HPV）是黏膜和皮肤上皮的常见病原体。鳞状上皮的生殖感染导致良性过度增生性疣、湿疣或乳头状瘤。高危 HPV 基因型 16 和 18 及密切相关类型的肛门生殖器黏膜持续性感染，偶尔会进展为女性和男性的高级别上皮内瘤变、原位癌和浸润性癌。HPV-16 也与一部分头颈部癌症有关。我们讨论了黏膜嗜性 HPV 与宿主调节蛋白和途径的相互作用，这些相互作用导致良性共存，并使 HPV DNA 扩增，或者相反，导致不再支持病毒产生的癌症。
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