致癌型人乳头瘤病毒。
Cancer associated human papillomaviruses.
机构信息
Division of Infectious Diseases, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Curr Opin Virol. 2012 Aug;2(4):459-66. doi: 10.1016/j.coviro.2012.05.004. Epub 2012 Jun 2.
Abstract
A small group of human papillomaviruses (HPVs) cause almost all cervical carcinoma and a significant percentage of other anogenital tract and oral carcinoma. Another group of HPVs causes non-melanoma skin cancers in genetically predisposed or immune suppressed patients upon UV exposure. HPV genome replication requires the host cell's DNA synthesis machinery and HPVs encode proteins that maintain differentiated epithelial cells in a replication competent state. The resulting rewiring of cellular signal transduction circuits triggers several innate cellular tumor suppressor responses that HPVs need to inactivate in order to establish persistent and/or productive infections. This review emphasizes this interplay between virus and the infected host cells and points out biological similarities and differences between different groups of HPVs.
摘要
一小部分人乳头瘤病毒（HPV）几乎会引起所有宫颈癌，以及相当大比例的其他生殖器官和口腔癌。另一组 HPV 会导致具有遗传易感性或免疫抑制的患者在暴露于 UV 后患上非黑色素瘤皮肤癌。HPV 基因组复制需要宿主细胞的 DNA 合成机制，HPV 编码的蛋白可使分化的上皮细胞维持在具有复制能力的状态。由此引发的细胞信号转导通路的重新布线触发了几种先天的细胞肿瘤抑制反应，HPV 需要使其失活，以建立持续性和/或生产性感染。这篇综述强调了病毒与受感染宿主细胞之间的这种相互作用，并指出了不同 HPV 组之间的生物学相似性和差异性。
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Cellular transformation by human papillomaviruses: lessons learned by comparing high- and low-risk viruses.人乳头瘤病毒引起的细胞转化：比较高危和低危病毒得出的经验教训。
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Cutaneous papillomavirus E6 oncoproteins associate with MAML1 to repress transactivation and NOTCH signaling.皮肤乳头瘤病毒 E6 癌蛋白与 MAML1 结合，抑制反式激活和 NOTCH 信号传导。
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Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses.系统鉴定不同型别人类乳头瘤病毒宿主细胞蛋白与 E7 癌蛋白的相互作用。
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Cancer. Another NOTCH for cancer.癌症。癌症的又一个Notch信号。 （注：Notch是一种细胞信号通路相关的分子，这里直接保留英文专业术语未翻译，因为在医学领域很多时候直接用英文术语更便于理解，如需完整翻译可补充更多背景知识后进一步翻译为“癌症。癌症的又一个Notch信号通路相关分子” ）
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