Bua Alessandra, Molicotti Paola, Cannas Sara, Ruggeri Melania, Olmeo Paolina, Zanetti Stefania
Department of Biomedical Sciences, University of Sassari, Italy.
New Microbiol. 2013 Apr;36(2):153-6. Epub 2013 Mar 31.
Until some time ago, the tuberculin skin test was the only available screening test for the diagnosis of tubercular infection. Now the new interferon-? release assay QuantiFERON-TB Gold shows promise of greater accuracy in the detection of Mycobacterium tuberculosis-infected subjects. The aim of our study was to evaluate the use of QuantiFERONTB Gold in children and to verify its agreement with the tuberculin skin test. A total of 27 children had a positive tuberculin skin test, 76 subjects were negative and the remaining 2 had a dubious Mantoux test. A positive QuantiFERONTB Gold result was obtained in 21 children while in 84 it was negative. No statistically significant difference was detected between the two assays, which showed a concordance of 90.57%. Our results demonstrated a good concordance between the tuberculin skin test and the interferon-? release assay, though the QuantiFERON-TB may have several advantages over the Mantoux test.
直到不久前，结核菌素皮肤试验还是诊断结核感染的唯一可用筛查试验。现在，新型干扰素γ释放试验（QuantiFERON-TB Gold）在检测结核分枝杆菌感染对象方面显示出更高准确性的前景。我们研究的目的是评估QuantiFERON-TB Gold在儿童中的应用，并验证其与结核菌素皮肤试验的一致性。共有27名儿童结核菌素皮肤试验呈阳性，76名受试者呈阴性，其余2名儿童结核菌素试验结果可疑。21名儿童QuantiFERON-TB Gold结果呈阳性，84名呈阴性。两种检测方法之间未检测到统计学上的显著差异，一致性为90.57%。我们的结果表明结核菌素皮肤试验与干扰素γ释放试验之间具有良好的一致性，尽管QuantiFERON-TB相对于结核菌素试验可能具有多个优势。
